Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4881126..4882807 | Replicon | chromosome |
| Accession | NZ_CP089427 | ||
| Organism | Klebsiella pneumoniae strain 1194 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | A9X66_RS24000 | Protein ID | WP_002885155.1 |
| Coordinates | 4881126..4882043 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | A9X66_RS24005 | Protein ID | WP_004151732.1 |
| Coordinates | 4882049..4882807 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A9X66_RS23980 (A9X66_023980) | 4876432..4877952 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| A9X66_RS23985 (A9X66_023985) | 4877949..4878947 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| A9X66_RS23990 (A9X66_023990) | 4878978..4879919 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| A9X66_RS23995 (A9X66_023995) | 4879994..4881001 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| A9X66_RS24000 (A9X66_024000) | 4881126..4882043 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| A9X66_RS24005 (A9X66_024005) | 4882049..4882807 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| A9X66_RS24010 (A9X66_024010) | 4882893..4883621 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| A9X66_RS24015 (A9X66_024015) | 4883894..4886041 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| A9X66_RS24020 (A9X66_024020) | 4886271..4886957 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T228225 WP_002885155.1 NZ_CP089427:c4882043-4881126 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T228225 NZ_CP123526:c53596-53192 [Arsenophonus nasoniae]
TTGATTAAATATTTACTCGATACAAATATCGTTATATTTACGATTAAACGGAAACCAGTATCGCTATTGCCTAAATTCAA
TCAACATACTAATCAACTGGCTATATCTGCGATAACGTTTGCAGAGCTAATTTTTGGTGCTGAAAAAAGCATGAACTCTG
CTAAAAATTTAGCAACAGTTAATGACTTTGTTTCTCGATTAACCGTTTTACCTTATGACGAACAAGCTGCATTTCATTAC
GGTGATATAAAGGCTAATTTTGAAAAAAAAGAAAAACCAATTGGTGACAATGACTTACATATAGCCGCTCATGCCAGAAG
CAAAGGGCTTGTTGTAGTAACAAACAACACTAGAGAGTTTGAAAGAGTTGAGGGGTTAAGAATCGAAGACTGGACACAAT
TATAA
TTGATTAAATATTTACTCGATACAAATATCGTTATATTTACGATTAAACGGAAACCAGTATCGCTATTGCCTAAATTCAA
TCAACATACTAATCAACTGGCTATATCTGCGATAACGTTTGCAGAGCTAATTTTTGGTGCTGAAAAAAGCATGAACTCTG
CTAAAAATTTAGCAACAGTTAATGACTTTGTTTCTCGATTAACCGTTTTACCTTATGACGAACAAGCTGCATTTCATTAC
GGTGATATAAAGGCTAATTTTGAAAAAAAAGAAAAACCAATTGGTGACAATGACTTACATATAGCCGCTCATGCCAGAAG
CAAAGGGCTTGTTGTAGTAACAAACAACACTAGAGAGTTTGAAAGAGTTGAGGGGTTAAGAATCGAAGACTGGACACAAT
TATAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT228225 WP_004151732.1 NZ_CP089427:c4882807-4882049 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT228225 NZ_CP123526:c53828-53589 [Arsenophonus nasoniae]
ATGATACAGCAAGGTAAAGTTTTTATGAGCAATCGAACTCAAAATGTTCGACTGCCAGCAGACACACGTTTTCCTGATGA
TGTTAAAGACGTTATTGTTCGAGTGAAGGGTAAAGAACGCATCATTTCTCCTGTACAAAACGCATGGGATAGTTTTTTCT
TATCAGAGCAGTCTGTAACGGATGATTTTTTATCAAACAGAACTGAACAGATAACAAGCGAAAGAGAATCCTTTGATTAA
ATGATACAGCAAGGTAAAGTTTTTATGAGCAATCGAACTCAAAATGTTCGACTGCCAGCAGACACACGTTTTCCTGATGA
TGTTAAAGACGTTATTGTTCGAGTGAAGGGTAAAGAACGCATCATTTCTCCTGTACAAAACGCATGGGATAGTTTTTTCT
TATCAGAGCAGTCTGTAACGGATGATTTTTTATCAAACAGAACTGAACAGATAACAAGCGAAAGAGAATCCTTTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GH11 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GQB5 |