Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4010160..4010779 Replicon chromosome
Accession NZ_CP089427
Organism Klebsiella pneumoniae strain 1194

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag A9X66_RS19775 Protein ID WP_002892050.1
Coordinates 4010561..4010779 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag A9X66_RS19770 Protein ID WP_002892066.1
Coordinates 4010160..4010534 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9X66_RS19760 (A9X66_019760) 4005312..4006505 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A9X66_RS19765 (A9X66_019765) 4006528..4009674 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
A9X66_RS19770 (A9X66_019770) 4010160..4010534 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
A9X66_RS19775 (A9X66_019775) 4010561..4010779 + 219 WP_002892050.1 HHA domain-containing protein Toxin
A9X66_RS19780 (A9X66_019780) 4010938..4011504 + 567 WP_002892030.1 maltose O-acetyltransferase -
A9X66_RS19785 (A9X66_019785) 4011476..4011616 - 141 WP_004147370.1 hypothetical protein -
A9X66_RS19790 (A9X66_019790) 4011637..4012107 + 471 WP_002892026.1 YlaC family protein -
A9X66_RS19795 (A9X66_019795) 4012082..4013533 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
A9X66_RS19800 (A9X66_019800) 4013634..4014332 + 699 WP_002892021.1 GNAT family protein -
A9X66_RS19805 (A9X66_019805) 4014329..4014469 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
A9X66_RS19810 (A9X66_019810) 4014469..4014732 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T228222 WP_002892050.1 NZ_CP089427:4010561-4010779 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T228222 NZ_CP123523:3068983-3069186 [Arsenophonus nasoniae]
ATGACTAAAATTGACTATCTGATGCGCTTAAGAAAATGTACGACTATCGAAACATTGGAGCGCGTAATCGAAAAAAACAA
ATATGAATTATCTGAAGACGAACTTGAGTTATTTTATTCTGCTGCCGACCATAGGTTAGCAGAACTCACAATGAATAAAC
TTTATGACAAAATTCCTTCGTCAGTTTGGAAGTATGTTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT228222 WP_002892066.1 NZ_CP089427:4010160-4010534 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT228222 NZ_CP123523:3068558-3068926 [Arsenophonus nasoniae]
ATGGATGAGTACTCACCAAGGAGTTATGACATCTTAGTGCTAAAGTATTTATGTGATGCTCTACATCGTGATGCGATGTT
AACTTTGCATAGGACAAAAACCCATTGGAAGAATGATCTTGGTTCCGACCAAAACGTTAAATTTAATGTATTAATTGATC
ATATCACAGATTTTATTGGTCAATTTAAATTAAAATATCCGAATAACGTAAATCTTTTTATTTTTATTGACGAATATTTG
GATGAAACTTATAACCTATTTGGTAAACCTGTAATGAGCCTAACAGATATTTCTGATTGGCAAAAAATGAATGAGCATTT
GTCTGAAATATTAACAAATGATATAAAGTATTCATTAAGTAACACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References