Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2674586..2676174 Replicon chromosome
Accession NZ_CP089427
Organism Klebsiella pneumoniae strain 1194

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag A9X66_RS13180 Protein ID WP_004199851.1
Coordinates 2674586..2675908 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag A9X66_RS13185 Protein ID WP_002904790.1
Coordinates 2675908..2676174 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9X66_RS13165 (A9X66_013165) 2669651..2672152 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
A9X66_RS13170 (A9X66_013170) 2672140..2673144 + 1005 WP_004199852.1 fimbrial protein -
A9X66_RS13175 (A9X66_013175) 2673277..2674569 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
A9X66_RS13180 (A9X66_013180) 2674586..2675908 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
A9X66_RS13185 (A9X66_013185) 2675908..2676174 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
A9X66_RS13190 (A9X66_013190) 2676440..2676766 - 327 WP_002904788.1 hydroxyisourate hydrolase -
A9X66_RS13195 (A9X66_013195) 2676763..2677263 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
A9X66_RS13200 (A9X66_013200) 2677241..2678620 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
A9X66_RS13205 (A9X66_013205) 2678966..2680120 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
A9X66_RS13210 (A9X66_013210) 2680101..2681024 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T228221 WP_004199851.1 NZ_CP089427:c2675908-2674586 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T228221 NZ_CP123523:c2754127-2753720 [Arsenophonus nasoniae]
GTGGTTCTTTGGAAATTTAATATCAATGTTTCGTGGCTGACGCAGCTTTTTTCAACGGGTGTTCATGTGGGAATTGGCTT
GTTAGTTTTCTTTTCATCTTGGCCACCAAATAATCTGGTCACTTGGTTGATAGCGACCTTATTGATTGTGGCAAGTTGGG
TAAGGAGTCAAAAAAATATTAGTCGTTGTAAAGGTAGCATAGTTTTACTTAATGGTAATAAGATACAGTGGAAAAAAAGC
GAATGGCTGATTGTTAAAAAACCTTGGTTTTGTTTTTTTGGTGTAAAACTTACTCTTCGTTCATGGCAATGTAATAAGCG
GATTCGGTTATGGATTGCTTCAGATAGTATGCCAGAAGAGGAATGGCGGAATTTAAATCAATTGCTGTTGCAGTACCCTG
ATATTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT228221 WP_002904790.1 NZ_CP089427:c2676174-2675908 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT228221 NZ_CP123523:c2754374-2754108 [Arsenophonus nasoniae]
ATGGATATCAATCATAAACCCAGGATCCACTGGGCATGTCGCAGAGGAATGCGTGAGTTGGACATCGCCATTATGCCTTT
TTTTGAGTATGAATATGATTCACTCACAGAGGATGAGAAATGTCTGTTTGTTCGTTTACTAGAGTGTGCAGATCCTGATT
TGTTCAACTGGTTGATGAATCATGGGCGTCCTGATGATGATGGTCTTTATCATATGATTCAATTGATACAGAGTAGAAAT
AAACAACGTGGTTCTTTGGAAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References