Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872116..872773 Replicon chromosome
Accession NZ_CP089427
Organism Klebsiella pneumoniae strain 1194

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag A9X66_RS04405 Protein ID WP_002916310.1
Coordinates 872363..872773 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag A9X66_RS04400 Protein ID WP_002916312.1
Coordinates 872116..872382 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9X66_RS04375 (A9X66_004375) 867272..868705 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
A9X66_RS04380 (A9X66_004380) 868824..869552 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
A9X66_RS04385 (A9X66_004385) 869602..869913 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
A9X66_RS04390 (A9X66_004390) 870077..870736 + 660 WP_002916317.1 hemolysin III family protein -
A9X66_RS04395 (A9X66_004395) 870887..871870 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
A9X66_RS04400 (A9X66_004400) 872116..872382 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
A9X66_RS04405 (A9X66_004405) 872363..872773 + 411 WP_002916310.1 protein YgfX Toxin
A9X66_RS04410 (A9X66_004410) 872780..873301 - 522 WP_002916308.1 flavodoxin FldB -
A9X66_RS04415 (A9X66_004415) 873402..874298 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
A9X66_RS04420 (A9X66_004420) 874321..875034 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A9X66_RS04425 (A9X66_004425) 875040..876773 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T228212 WP_002916310.1 NZ_CP089427:872363-872773 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T228212 NZ_CP123504:c2639453-2639046 [Arsenophonus nasoniae]
GTGGTTCTTTGGAAATTTAATATCAATGTTTCGTGGCTGACGCAGCTTTTTTCAACGGGTGTTCATGTGGGAATTGGCTT
GTTAGTTTTCTTTTCATCTTGGCCACCAAATAATCTGGTCACTTGGTTGATAGCGACCTTATTGATTGTGGCAAGTTGGG
TAAGGAGTCAAAAAAATATTAGTCGTTGTAAAGGTAGCATAGTTTTACTTAATGGTAATAAGATACAGTGGAAAAAAAGC
GAATGGCTGATTGTTAAAAAACCTTGGTTTTGTTTTTTTGGTGTAAAACTTACTCTTCGTTCATGGCAATGTAATAAGCG
GATTCGGTTATGGATTGCTTCAGATAGTATGCCAGAAGAGGAATGGCGGAATTTAAATCAATTGCTGTTGCAGTACCCTG
ATATTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT228212 WP_002916312.1 NZ_CP089427:872116-872382 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228212 NZ_CP123504:c2639700-2639434 [Arsenophonus nasoniae]
ATGGATATCAATCATAAACCCAGGATCCACTGGGCATGTCGCAGAGGAATGCGTGAGTTGGACATCGCCATTATGCCTTT
TTTTGAGTATGAATATGATTCACTCACAGAGGATGAGAAATGTCTGTTTGTTCGTTTACTAGAGTGTGCAGATCCTGATT
TGTTCAACTGGTTGATGAATCATGGGCGTCCTGATGATGATGGTCTTTATCATATGATTCAATTGATACAGAGTAGAAAT
AAACAACGTGGTTCTTTGGAAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References