Detailed information of TA system TA022821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1050125..1050623
• Replicon: chromosome
• Accession: NC_010582
• Organism: Streptococcus pneumoniae CGSP14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPCG_RS05590
• Protein ID: WP_001812387.1
• Coordinates: 1050369..1050623 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: SPCG_RS05585
• Protein ID: WP_000208080.1
• Coordinates: 1050125..1050367 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPCG_RS05565	1045947..1047122	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
SPCG_RS05570	1047177..1047881	+	705	WP_000722076.1	response regulator transcription factor	-
SPCG_RS05575	1047874..1049223	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
SPCG_RS05580	1049225..1050034	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
SPCG_RS05585	1050125..1050367	+	243	WP_000208080.1	hypothetical protein	Antitoxin
SPCG_RS05590	1050369..1050623	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPCG_RS05595	1050670..1051322	+	653	Protein_1047	potassium channel family protein	-
SPCG_RS05600	1051582..1052568	-	987	WP_000204727.1	L-lactate dehydrogenase	-
SPCG_RS05605	1052762..1055230	+	2469	WP_001152992.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T22821 WP_001812387.1 NC_010582:1050369-1050623 [Streptococcus pneumoniae CGSP14]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T22821 NC_010582:1050369-1050623 [Streptococcus pneumoniae CGSP14]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT22821 WP_000208080.1 NC_010582:1050125-1050367 [Streptococcus pneumoniae CGSP14]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT22821 NC_010582:1050125-1050367 [Streptococcus pneumoniae CGSP14]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7