Detailed information of TA system TA228203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2498549..2499191
• Replicon: chromosome
• Accession: NZ_CP089414
• Organism: Dyella terrae strain Ely Copper Mine

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DYST_RS10775
• Protein ID: WP_239951802.1
• Coordinates: 2499015..2499191 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DYST_RS10770
• Protein ID: WP_239951801.1
• Coordinates: 2498549..2498986 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYST_RS10745 (DYST_02202)	2493638..2494588	-	951	WP_239951796.1	hypothetical protein	-
DYST_RS10750 (DYST_02203)	2494806..2495969	+	1164	WP_239951797.1	RHS repeat-associated core domain-containing protein	-
DYST_RS10755 (DYST_02204)	2495982..2496509	+	528	WP_239951798.1	hypothetical protein	-
DYST_RS10760 (DYST_02206)	2497165..2497395	+	231	WP_239951799.1	hypothetical protein	-
DYST_RS10765 (DYST_02207)	2497765..2498568	-	804	WP_239951800.1	hypothetical protein	-
DYST_RS10770 (DYST_02208)	2498549..2498986	-	438	WP_239951801.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DYST_RS10775 (DYST_02209)	2499015..2499191	-	177	WP_239951802.1	type II toxin-antitoxin system HicA family toxin	Toxin
DYST_RS10780 (DYST_02210)	2499449..2500177	-	729	WP_239951803.1	glycosyltransferase family A protein	-
DYST_RS10785 (DYST_02211)	2500213..2501604	-	1392	WP_239951804.1	UDP-N-acetylglucosamine-transferase	-
DYST_RS10790 (DYST_02212)	2501672..2503771	-	2100	WP_239951806.1	peptidase domain-containing ABC transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2482783..2500177	17394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (9-60)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6782.88 Da
• Isoelectric Point: 10.8172

>T228203 WP_239951802.1 NZ_CP089414:c2499191-2499015 [Dyella terrae]
MKYSEFIRWLRAQGVIFERQRGSHQFVKFDGNTSVVPNHGSKEIPEPLRKKILKDLGL

Nucleotide

• Length: 177 bp

>T228203 NZ_CP123498:2251217-2251420 [Arsenophonus nasoniae]
ATGACTAAAATTGACTATCTGATGCGCTTAAGAAAATGTACGACTATCGAAACATTGGAGCGCGTAATCGAAAAAAACAA
ATATGAATTATTTGAAGACGAACTTGAGTTATTTTATTCTGCTGCCGACCATAGGTTAGCAGAACTCACAATGAATAAAC
TTTATGACAAAATTCCTTCGTCAGTTTGGAAGTATGTTCGCTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 15789.15 Da
• Isoelectric Point: 6.3330

>AT228203 WP_239951801.1 NZ_CP089414:c2498986-2498549 [Dyella terrae]
MQYAIKLAEADGAFVATCRDLPAFNSVGDTVEEALRESVDAIALVLQSYMDEREPIPTATDKKRGEHWVALPALDVAKVG
LYQAMQTKGVRKADLGRMLGMHAPQVDRLLDLAHKSKLEQVEGALAHLGYRVNVSVEPVGVRHAA

Nucleotide

• Length: 438 bp

>AT228203 NZ_CP123498:2250792-2251160 [Arsenophonus nasoniae]
ATGGATGAGTACTCACCAAGGAGTTATGACATCTTAGTGCTAAAGTATTTATGTGATGCTCTACATCGTGATGCGATGTT
AACTTTGCATAGGACAAAAACCCATTGGAAGAATGATCTTGGTTCCGACCAAAACGTTAAATTTAATGTATTAATTGATC
ATATCACAGATTTTATTGGTCAATTTAAATTAAAATATCCGAATAACGTAAATCTTTTTATTTTTATTGACGAATATTTG
GATGAAACTTATAACCTATTTGGTAAACCTGTAATGAGCCTAACAGATATTTCTGATTGGCAAAAAATGAATGAGCATTT
GGCTGAAATATTAACAAATGATATAAAGTATTCATTAAGTAACACTTGA