Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5606601..5607258 Replicon chromosome
Accession NZ_CP089407
Organism Klebsiella michiganensis strain Kox101

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag LUW94_RS26620 Protein ID WP_004854060.1
Coordinates 5606848..5607258 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag LUW94_RS26615 Protein ID WP_004124953.1
Coordinates 5606601..5606867 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW94_RS26600 (LUW94_26600) 5601835..5602260 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
LUW94_RS26605 (LUW94_26605) 5602381..5605179 - 2799 WP_014226794.1 transcriptional regulator DagR -
LUW94_RS26610 (LUW94_26610) 5605373..5606356 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
LUW94_RS26615 (LUW94_26615) 5606601..5606867 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
LUW94_RS26620 (LUW94_26620) 5606848..5607258 + 411 WP_004854060.1 protein YgfX Toxin
LUW94_RS26625 (LUW94_26625) 5607267..5607788 - 522 WP_014226792.1 flavodoxin FldB -
LUW94_RS26630 (LUW94_26630) 5607910..5608806 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
LUW94_RS26635 (LUW94_26635) 5608829..5609542 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LUW94_RS26640 (LUW94_26640) 5609548..5611281 + 1734 WP_224261873.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T228196 WP_004854060.1 NZ_CP089407:5606848-5607258 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T228196 NZ_CP123498:c851973-851722 [Arsenophonus nasoniae]
ATGAAAACAGTTAATTATACCGATGCAAGACAAAACTTAACGTCTATCATGAATGAAGCGATAGATGATCGGATCCCAAT
TTTAATCACTAGACAAAAAGGCGTTCCTTGCGTTTTGTTATCACTTGATGAATACCAATCTTTAGAAGAGACAGCCTACC
TGCTGCGCTCACCAGCTAATGCTCGTCATCTATTGGATTCGATTGACGAACTTAATGCCGGTAAAGGAATTGAAAGAGAT
ATTCAGGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT228196 WP_004124953.1 NZ_CP089407:5606601-5606867 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228196 NZ_CP123498:c851725-851468 [Arsenophonus nasoniae]
ATGAAATTAATATTTACTGAACAATCATGGAACGATTACCTTTATTGGCAGCAAATAGATAAAAAGATAATTAAACGTAT
TAATGAATTAATTAAAGAAATTAAAAGAGAACCTTTTTCTGGTATCGGTAAGCCCGAGCCTTTAAAACACAATTTAACCG
GTTTTTGGTCGCGCAGAATAACTGAGGAACACCGTTTAATATACCGGTTAACAGATAAGGGCTTAGAGATACCTTCATGT
CGTTATCTCTATAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References