228195

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 5410032..5410624 Replicon chromosome
Accession NZ_CP089407
Organism Klebsiella michiganensis strain Kox101

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag LUW94_RS25700 Protein ID WP_004105955.1
Coordinates 5410250..5410624 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag LUW94_RS25695 Protein ID WP_004105957.1
Coordinates 5410032..5410253 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW94_RS25675 (LUW94_25675) 5405589..5406143 + 555 WP_202019388.1 YgjV family protein -
LUW94_RS25680 (LUW94_25680) 5406162..5407409 - 1248 WP_004105963.1 serine/threonine transporter SstT -
LUW94_RS25685 (LUW94_25685) 5407664..5408632 - 969 WP_048260487.1 TerC family protein -
LUW94_RS25690 (LUW94_25690) 5408883..5409872 - 990 WP_049083892.1 Gfo/Idh/MocA family oxidoreductase -
LUW94_RS25695 (LUW94_25695) 5410032..5410253 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LUW94_RS25700 (LUW94_25700) 5410250..5410624 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LUW94_RS25705 (LUW94_25705) 5410604..5411107 - 504 WP_025108311.1 M48 family metallopeptidase -
LUW94_RS25710 (LUW94_25710) 5411186..5412829 - 1644 WP_202019389.1 glycoside hydrolase family 43 protein -
LUW94_RS25715 (LUW94_25715) 5412958..5413824 - 867 WP_038423701.1 AraC family transcriptional regulator -
LUW94_RS25720 (LUW94_25720) 5413932..5415275 + 1344 WP_046878299.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T228195 WP_004105955.1 NZ_CP089407:5410250-5410624 [Klebsiella michiganensis]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T228195 NZ_CP123498:c851725-851468 [Arsenophonus nasoniae]
ATGAAATTAATATTTACTGAACAATCATGGAACGATTACCTTTATTGGCAGCAAATAGATAAAAAGATAATTAAACGTAT
TAATGAATTAATTAAAGAAATTAAAAGAGAACCTTTTTCTGGTATCGGTAAGCCCGAGCCTTTAAAACACAATTTAACCG
GTTTTTGGTCGCGCAGAATAACTGAGGAACACCGTTTAATATACCGGTTAACAGATAAGGGCTTAGAGATACCTTCATGT
CGTTATCTCTATAATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT228195 WP_004105957.1 NZ_CP089407:5410032-5410253 [Klebsiella michiganensis]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT228195 NZ_CP123498:c851973-851722 [Arsenophonus nasoniae]
ATGAAAACAGTTAATTATACCGATGCAAGACAAAACTTAACGTCTATCATGAATGAAGCGATAGATGATCGGATCCCAAT
TTTAATCACTAGACAAAAAGGCGTTCCTTGCGTTTTGTTATCACTTGATGAATACCAATCTTTAGAAGAGACAGCCTACC
TGCTGCGCTCACCAGCTAATGCTCGTCATCTATTGGATTCGATTGACGAACTTAATGCCGGTAAAGGAATTGAAAGAGAT
ATTCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References