Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 3558289..3559108 Replicon chromosome
Accession NZ_CP089407
Organism Klebsiella michiganensis strain Kox101

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag LUW94_RS17000 Protein ID WP_004110819.1
Coordinates 3558851..3559108 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A2J4Z0A2
Locus tag LUW94_RS16995 Protein ID WP_025107249.1
Coordinates 3558289..3558840 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW94_RS16975 (LUW94_16975) 3553658..3555055 + 1398 WP_202019243.1 MFS transporter -
LUW94_RS16980 (LUW94_16980) 3555178..3556518 + 1341 WP_025107247.1 carbohydrate porin -
LUW94_RS16985 (LUW94_16985) 3556643..3557389 - 747 WP_224226570.1 class I SAM-dependent methyltransferase -
LUW94_RS16990 (LUW94_16990) 3557765..3558175 - 411 Protein_3353 class I SAM-dependent methyltransferase -
LUW94_RS16995 (LUW94_16995) 3558289..3558840 - 552 WP_025107249.1 N-acetyltransferase Antitoxin
LUW94_RS17000 (LUW94_17000) 3558851..3559108 - 258 WP_004110819.1 YjhX family toxin Toxin
LUW94_RS17005 (LUW94_17005) 3559784..3560968 + 1185 WP_014228054.1 mannonate dehydratase -
LUW94_RS17010 (LUW94_17010) 3561042..3562517 + 1476 WP_014228053.1 fructuronate reductase -
LUW94_RS17015 (LUW94_17015) 3562656..3563432 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T228192 WP_004110819.1 NZ_CP089407:c3559108-3558851 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T228192 NZ_CP123498:c545098-544814 [Arsenophonus nasoniae]
ATGAAAACAAAACCAGAATTATTTGATGTGGTCGATTACCTCGATAATGAAGAAGATATACAGGCATATCTAAATGCTGC
GCTGGATGAAGACGATGAAAACTATTTTTTAGTGGCACTAGGAAACGTTGCCAGAGCAAGAAATATTAGTCACCTTTCAA
AAGAAACTGGAATGAGCCGTGAAGGAATTTACAAGGCACTTTCCGGTGCGGGAAATCCATCATTTAAAACTATATCAAAA
ATCTCTAAAGCATTAGGTTTAAAATTACACTTTTCAGGGGCCTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19930.69 Da        Isoelectric Point: 6.4913

>AT228192 WP_025107249.1 NZ_CP089407:c3558840-3558289 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT228192 NZ_CP123498:c545396-545100 [Arsenophonus nasoniae]
ATGATTGAAATCAGGCAAACCGAAGAAGTTAAAAAATGGCTAAAAGGATTAAAAGATAAAATAGCCAAAGCAAAAATTTT
AACACGGATTGAACGGATGAAAGAAGGTAACTATGGGGATGTAGAACCGATAGGTGATGGATATTCAGAATTAAAAATCC
ATCAAGGCAAAGGCTACAGGGTATATTTTGCCACACGGAACAATGAAATTATTTTATTGCTTTGTGGTGGAGATAAAGCA
ACACAACAAGCCGATATTAAAAAAGCAAAGCAGATAGCGAAACAATGGGGGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4Z0A2

References