Detailed information of TA system TA022819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 4094682..4095309
• Replicon: chromosome
• Accession: NC_010581
• Organism: Beijerinckia indica subsp. indica ATCC 9039

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B2IG92
• Locus tag: BIND_RS18365
• Protein ID: WP_012386514.1
• Coordinates: 4094902..4095309 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B2IG91
• Locus tag: BIND_RS18360
• Protein ID: WP_012386513.1
• Coordinates: 4094682..4094912 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BIND_RS18350	4091690..4092907	+	1218	WP_012386511.1	2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase	-
BIND_RS18355	4093131..4094528	+	1398	WP_041779041.1	dihydrolipoyl dehydrogenase	-
BIND_RS18360	4094682..4094912	+	231	WP_012386513.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BIND_RS18365	4094902..4095309	+	408	WP_012386514.1	PIN domain-containing protein	Toxin
BIND_RS20320	4095377..4097224	+	1848	WP_081433802.1	trypsin-like peptidase domain-containing protein	-
BIND_RS18380	4097836..4098369	-	534	WP_012386516.1	RecX family transcriptional regulator	-
BIND_RS18385	4098369..4099771	-	1403	Protein_3590	argininosuccinate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-114)

Antitoxin

• SpoVT-AbrB domain (5-35)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15108.22 Da
• Isoelectric Point: 4.4217

>T22819 WP_012386514.1 NC_010581:4094902-4095309 [Beijerinckia indica subsp. indica ATCC 9039]
MPGSFFDTNVLLYLASGDPVKADQAEKVINEGGMISVQVLNEITNVARRKMCLSWAETRAFLSMIRDLLQVHPMTLETHE
TGLALAERYNLSTYDAMIAASALQNDCDTLWSEDMQDGMVIQNQVRIIDPFHSRG

Nucleotide

• Length: 408 bp

>T22819 NC_010581:4094902-4095309 [Beijerinckia indica subsp. indica ATCC 9039]
ATGCCCGGTAGCTTCTTCGATACGAATGTCTTGCTCTACCTCGCATCGGGCGATCCTGTAAAAGCGGATCAGGCGGAGAA
GGTCATCAATGAAGGCGGCATGATCAGTGTGCAAGTCCTGAACGAAATCACGAATGTTGCCCGGCGAAAAATGTGTCTGT
CATGGGCGGAGACCCGTGCGTTTCTTTCGATGATTCGCGATTTGCTGCAGGTCCATCCTATGACCCTTGAAACGCATGAA
ACAGGCCTCGCCCTCGCCGAGCGCTACAATCTCTCGACTTATGACGCCATGATCGCTGCCTCAGCGCTCCAGAACGATTG
CGACACGCTTTGGTCGGAGGACATGCAGGATGGGATGGTGATCCAAAACCAAGTCAGGATTATCGACCCGTTTCATTCAA
GAGGCTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8668.98 Da
• Isoelectric Point: 10.2844

>AT22819 WP_012386513.1 NC_010581:4094682-4094912 [Beijerinckia indica subsp. indica ATCC 9039]
MQVAKWGNSLAVRLPAALVEALALKEGDEIEIHIADAREFAVTRKPGREELLRRLRAFRGRLPPDFKFDRDEANAR

Nucleotide

• Length: 231 bp

>AT22819 NC_010581:4094682-4094912 [Beijerinckia indica subsp. indica ATCC 9039]
ATGCAGGTCGCGAAATGGGGCAATAGCCTCGCCGTTCGCCTTCCCGCCGCGCTCGTCGAAGCCCTGGCGTTGAAAGAGGG
GGATGAGATCGAAATCCATATTGCCGATGCGCGAGAATTTGCCGTGACGCGCAAACCCGGCCGAGAGGAATTGCTGCGGC
GTCTTCGGGCCTTCCGCGGGCGTCTTCCTCCCGATTTCAAGTTTGATCGGGATGAGGCGAATGCCCGGTAG

Structures

Toxin

• AlphaFold DB: B2IG92

Antitoxin

• AlphaFold DB: B2IG91