Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 111628..112367 Replicon plasmid pKOX205_1
Accession NZ_CP089404
Organism Klebsiella pasteurii strain Kox205

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LUW96_RS28930 Protein ID WP_117389532.1
Coordinates 111882..112367 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag LUW96_RS28925 Protein ID WP_049095044.1
Coordinates 111628..111894 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW96_RS28895 (LUW96_28895) 106919..107585 + 667 Protein_116 DUF4113 domain-containing protein -
LUW96_RS28900 (LUW96_28900) 107707..108150 + 444 WP_004026357.1 DUF2384 domain-containing protein -
LUW96_RS28905 (LUW96_28905) 108147..108617 + 471 WP_048984280.1 RES family NAD+ phosphorylase -
LUW96_RS28910 (LUW96_28910) 108728..108988 - 261 WP_004026352.1 hypothetical protein -
LUW96_RS28915 (LUW96_28915) 109497..110866 + 1370 WP_087661561.1 IS3 family transposase -
LUW96_RS28920 (LUW96_28920) 111067..111495 + 429 WP_004901287.1 GFA family protein -
LUW96_RS28925 (LUW96_28925) 111628..111894 + 267 WP_049095044.1 DUF1778 domain-containing protein Antitoxin
LUW96_RS28930 (LUW96_28930) 111882..112367 + 486 WP_117389532.1 GNAT family N-acetyltransferase Toxin
LUW96_RS28935 (LUW96_28935) 112786..114126 + 1341 WP_049095043.1 ISNCY family transposase -
LUW96_RS28940 (LUW96_28940) 114376..114732 - 357 Protein_125 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..149463 149463
- inside IScluster/Tn - - 110141..114732 4591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17668.49 Da        Isoelectric Point: 10.3370

>T228181 WP_117389532.1 NZ_CP089404:111882-112367 [Klebsiella pasteurii]
VGRITAPEPLFSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

>T228181 NZ_CP123431:124512-124928 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10163.63 Da        Isoelectric Point: 4.5256

>AT228181 WP_049095044.1 NZ_CP089404:111628-111894 [Klebsiella pasteurii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDELAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT228181 NZ_CP123431:124285-124515 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References