Detailed information of TA system TA022817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3034737..3035328
• Replicon: chromosome
• Accession: NC_010581
• Organism: Beijerinckia indica subsp. indica ATCC 9039

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BIND_RS20745
• Protein ID: WP_012385589.1
• Coordinates: 3034737..3034925 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B2IJC1
• Locus tag: BIND_RS13445
• Protein ID: WP_012385590.1
• Coordinates: 3034930..3035328 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BIND_RS20740	3031041..3031454	-	414	WP_158304392.1	transposase	-
BIND_RS13435	3031691..3033334	+	1644	Protein_2635	recombinase family protein	-
BIND_RS13440	3033408..3034631	-	1224	WP_012385588.1	site-specific integrase	-
BIND_RS20745	3034737..3034925	+	189	WP_012385589.1	type II toxin-antitoxin system HicA family toxin	Toxin
BIND_RS13445	3034930..3035328	+	399	WP_012385590.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BIND_RS21375	3035546..3036076	+	531	WP_012385591.1	hypothetical protein	-
BIND_RS13450	3036080..3036325	+	246	WP_012385592.1	hypothetical protein	-
BIND_RS13455	3036745..3037212	+	468	WP_148210645.1	hypothetical protein	-
BIND_RS13460	3037301..3038359	+	1059	WP_012385594.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3017363..3041444	24081

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6697.77 Da
• Isoelectric Point: 11.4350

>T22817 WP_012385589.1 NC_010581:3034737-3034925 [Beijerinckia indica subsp. indica ATCC 9039]
MNSRAVIAALEADGWKKVGQKGSHVQFKHPTKPGRVTVPHPSRELPKGTLRSIEKQAALSIG

Nucleotide

• Length: 189 bp

>T22817 NC_010581:3034737-3034925 [Beijerinckia indica subsp. indica ATCC 9039]
ATGAACAGCCGCGCCGTCATAGCCGCCCTTGAAGCCGATGGATGGAAAAAGGTCGGCCAGAAAGGCAGCCACGTTCAATT
CAAACATCCGACGAAACCGGGCCGGGTGACTGTTCCCCATCCCTCGCGCGAATTGCCCAAAGGCACATTACGGAGCATCG
AGAAGCAAGCTGCTCTCAGTATAGGATAG

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14040.89 Da
• Isoelectric Point: 4.5200

>AT22817 WP_012385590.1 NC_010581:3034930-3035328 [Beijerinckia indica subsp. indica ATCC 9039]
MRQYIALIHKEADSDYGVSFPDFPGCITAGTTLDEARAMAEEALALHIEGLAEDGEAVPEPSSLETVMAAQENRRGVAIL
VPAPAAAPKSVRVNVTLPEDVLAQIDRYAESHGLTRSGFLAQAAKHAMLEKA

Nucleotide

• Length: 399 bp

>AT22817 NC_010581:3034930-3035328 [Beijerinckia indica subsp. indica ATCC 9039]
ATGCGCCAATACATCGCTCTCATCCACAAGGAAGCCGATAGCGATTATGGGGTTTCCTTCCCAGACTTCCCCGGCTGCAT
CACGGCCGGGACGACGCTCGATGAAGCCCGCGCCATGGCCGAAGAAGCCCTTGCTCTGCATATCGAAGGGCTGGCGGAAG
ATGGAGAGGCAGTTCCGGAGCCATCTTCTCTTGAAACGGTGATGGCCGCTCAGGAAAACCGGCGGGGGGTGGCGATCCTT
GTTCCCGCTCCTGCCGCAGCGCCAAAATCCGTCCGGGTCAATGTGACACTACCCGAGGACGTTCTTGCGCAAATCGATCG
CTACGCTGAGAGCCACGGCCTAACCCGCTCTGGCTTCCTCGCCCAGGCTGCGAAACATGCCATGCTTGAAAAGGCGTGA

Structures

Antitoxin

• AlphaFold DB: B2IJC1