Detailed information of TA system TA228169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2563402..2564221
• Replicon: chromosome
• Accession: NZ_CP089403
• Organism: Klebsiella pasteurii strain Kox205

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: LUW96_RS12100
• Protein ID: WP_004129235.1
• Coordinates: 2563402..2563659 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A2J4V3L3
• Locus tag: LUW96_RS12105
• Protein ID: WP_049115078.1
• Coordinates: 2563670..2564221 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUW96_RS12085 (LUW96_12085)	2559168..2559944	-	777	WP_004129229.1	Uxu operon transcriptional regulator	-
LUW96_RS12090 (LUW96_12090)	2560082..2561557	-	1476	WP_112165899.1	fructuronate reductase	-
LUW96_RS12095 (LUW96_12095)	2561634..2562818	-	1185	WP_049115080.1	mannonate dehydratase	-
LUW96_RS12100 (LUW96_12100)	2563402..2563659	+	258	WP_004129235.1	YjhX family toxin	Toxin
LUW96_RS12105 (LUW96_12105)	2563670..2564221	+	552	WP_049115078.1	N-acetyltransferase	Antitoxin
LUW96_RS12110 (LUW96_12110)	2564335..2564742	+	408	Protein_2347	class I SAM-dependent methyltransferase	-
LUW96_RS12115 (LUW96_12115)	2565121..2565867	+	747	WP_117085590.1	class I SAM-dependent methyltransferase	-
LUW96_RS12120 (LUW96_12120)	2566262..2567308	+	1047	WP_004129248.1	LacI family DNA-binding transcriptional regulator	-
LUW96_RS12125 (LUW96_12125)	2567352..2567771	-	420	WP_049115076.1	RbsD/FucU family protein	-
LUW96_RS12130 (LUW96_12130)	2567820..2568584	-	765	WP_049115075.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T228169 WP_004129235.1 NZ_CP089403:2563402-2563659 [Klebsiella pasteurii]
MNLSRQEQRTLHVLAKGGRIAHVRDTSGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T228169 NZ_CP123403:c1010432-1010139 [Trueperella pyogenes]
ATGGGAGTAAAAATCAGCACCTGGGATGCCAGCGAATACCTTGAAACCAAGGAAGATATTGCTGCCTACCTGAACGCGGC
ACTCGAAGAGGGCGACCCGGCTCTCCTGCAGGTCGCACTTGGTGATGTCGCCAAAGCGCGTGGTGTGACCGCTATCGCGC
GAGAAGCCGGTGTTGGACGCGAGTCTCTCTACAAGTCGCTTTCCGAAAACGGCAATCCGTCCTGGCGGACCATCACAAAG
GTTCTCACTGCACTCGGGCTGAAGATCGAAGTCAAAGCCATTGCGTTAGCGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20051.94 Da
• Isoelectric Point: 7.5404

>AT228169 WP_049115078.1 NZ_CP089403:2563670-2564221 [Klebsiella pasteurii]
MTNHSFTFHVASEGDTDDILNVETRAFGYSKEARLVASLLNDESASPTLSLLARHNGKAVGHILFTRAMFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGALIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQRLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT228169 NZ_CP123403:c1010737-1010423 [Trueperella pyogenes]
GTGAAGATTCGGCAAACCGACGTGTATGCTCACTGGTTTCGCGAGCTAAAAGATGTCCAGAGCAAGGCCCGAATCAATAT
TGCACTTCAGCGTTGCAAAATAGCTGGCGAAGTAGTGGGTGACGTCAAGCCGGTTGGTGATGGCGTTTTTGAGATGCGAA
TTCACGTTGGCCCCGGCTATCGGATTTACTACATGTCAAGAGGGAACCAACTTATGCTACTAGTCATTGGTGGTGATAAG
TCCACCCAGCAGCGTGACATAACCAAAGCTAAACAGCTTGCAACAGAAATTATTAGGGAGGGATCATGGGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2J4V3L3