Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 2057115..2057818 | Replicon | chromosome |
| Accession | NZ_CP089403 | ||
| Organism | Klebsiella pasteurii strain Kox205 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | LUW96_RS09800 | Protein ID | WP_042093716.1 |
| Coordinates | 2057477..2057818 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | LUW96_RS09795 | Protein ID | WP_042093718.1 |
| Coordinates | 2057115..2057456 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUW96_RS09760 (LUW96_09760) | 2052264..2053139 | + | 876 | WP_042093731.1 | GTPase family protein | - |
| LUW96_RS09765 (LUW96_09765) | 2053383..2054099 | + | 717 | WP_042093729.1 | WYL domain-containing protein | - |
| LUW96_RS09770 (LUW96_09770) | 2054135..2054587 | + | 453 | WP_077778718.1 | hypothetical protein | - |
| LUW96_RS09775 (LUW96_09775) | 2054659..2055132 | + | 474 | WP_042093727.1 | hypothetical protein | - |
| LUW96_RS09780 (LUW96_09780) | 2055253..2056101 | + | 849 | WP_042093725.1 | DUF932 domain-containing protein | - |
| LUW96_RS09785 (LUW96_09785) | 2056106..2056549 | + | 444 | WP_042093723.1 | antirestriction protein | - |
| LUW96_RS09790 (LUW96_09790) | 2056562..2057104 | + | 543 | WP_042093722.1 | DNA repair protein RadC | - |
| LUW96_RS09795 (LUW96_09795) | 2057115..2057456 | + | 342 | WP_042093718.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LUW96_RS09800 (LUW96_09800) | 2057477..2057818 | + | 342 | WP_042093716.1 | TA system toxin CbtA family protein | Toxin |
| LUW96_RS09805 (LUW96_09805) | 2058077..2059084 | + | 1008 | WP_042093714.1 | restriction endonuclease | - |
| LUW96_RS09810 (LUW96_09810) | 2059313..2060056 | - | 744 | WP_049113954.1 | hypothetical protein | - |
| LUW96_RS09815 (LUW96_09815) | 2060090..2060551 | - | 462 | WP_049113955.1 | hypothetical protein | - |
| LUW96_RS09820 (LUW96_09820) | 2060717..2061151 | - | 435 | WP_049113956.1 | VOC family protein | - |
| LUW96_RS09825 (LUW96_09825) | 2061298..2061621 | - | 324 | WP_004128377.1 | endoribonuclease SymE | - |
| LUW96_RS09830 (LUW96_09830) | 2061911..2062705 | - | 795 | WP_049113957.1 | DNA/RNA non-specific endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2027854..2061621 | 33767 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12741.73 Da Isoelectric Point: 8.0583
>T228168 WP_042093716.1 NZ_CP089403:2057477-2057818 [Klebsiella pasteurii]
MKTLPATNPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVILEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRHRISAAR
MKTLPATNPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVILEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRHRISAAR
Download Length: 342 bp
>T228168 NZ_CP123381:c4609338-4608763 [Gordonia sp. SMJS1]
GTGACTCCGCGGCTCGATCTGGTCGTCGGATGCAACGGCGCGGGCAAGTCGACGCTGGTCGAGCGTCATCTGCAACCCCT
GCTGCATGTGCCCTTCGTCAACGCCGACCTGATCGCCCGGCAGCGGTGGCCCGACTCCGCGGAAGCCCATTCCTACGACG
CCGCCCGGTTGGCGGCGGCGACCCGCGACACTCTCATCGAGCGCGGCACCTCGTTCATCGCCGAGACGGTCTTCTCGCAC
CCCTCGAAACTGGAGCTCATCGAACGTGCGCACACCGCCGGATACCGAGTCGCGCTGCACGTCGTGATGATCCCCGAGGC
TCTCGCGGTCCATCGCGTCCGATTGCGCGTGGACAGTGGCGGGCACGCGGTCCCCGAGGTCAAGATCCGCGAGCGGTTCC
GACGCCTGTGGCCGCTCGTCCGCACGGCCATCGCGCGGAGTGACCTGGCAACCGTGTACGCCAACGAGCGACCGACCACG
CGCATCGTCGCGCGGTACGTCGACGGTCTGGTCGCCGGCGTACCCGACTGGCCGGACTGGACGCCGGGTGCGCTGACGGA
TACGAAGGCACGATGA
GTGACTCCGCGGCTCGATCTGGTCGTCGGATGCAACGGCGCGGGCAAGTCGACGCTGGTCGAGCGTCATCTGCAACCCCT
GCTGCATGTGCCCTTCGTCAACGCCGACCTGATCGCCCGGCAGCGGTGGCCCGACTCCGCGGAAGCCCATTCCTACGACG
CCGCCCGGTTGGCGGCGGCGACCCGCGACACTCTCATCGAGCGCGGCACCTCGTTCATCGCCGAGACGGTCTTCTCGCAC
CCCTCGAAACTGGAGCTCATCGAACGTGCGCACACCGCCGGATACCGAGTCGCGCTGCACGTCGTGATGATCCCCGAGGC
TCTCGCGGTCCATCGCGTCCGATTGCGCGTGGACAGTGGCGGGCACGCGGTCCCCGAGGTCAAGATCCGCGAGCGGTTCC
GACGCCTGTGGCCGCTCGTCCGCACGGCCATCGCGCGGAGTGACCTGGCAACCGTGTACGCCAACGAGCGACCGACCACG
CGCATCGTCGCGCGGTACGTCGACGGTCTGGTCGCCGGCGTACCCGACTGGCCGGACTGGACGCCGGGTGCGCTGACGGA
TACGAAGGCACGATGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12883.62 Da Isoelectric Point: 6.6222
>AT228168 WP_042093718.1 NZ_CP089403:2057115-2057456 [Klebsiella pasteurii]
MKYTELENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTDEINPRH
ARCVTLYHNGFTCEADTLGSCGYVYVAVYPTHR
MKYTELENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTDEINPRH
ARCVTLYHNGFTCEADTLGSCGYVYVAVYPTHR
Download Length: 342 bp
>AT228168 NZ_CP123381:c4609718-4609335 [Gordonia sp. SMJS1]
ATGAGCACTGGTACGGACAAGGTGACCCGGCTGTCTGCTGCGTTGGTGACCGATGCGGCCCGGGAGGGCGCGCGAGAGCA
GCGGTCGGCGCGGCAGCAACTCGAACACTGGGCGCGTCTGGGGCGCAGCGTCTCGCAGCGCACCACCGCGTCGCGTCAGC
GGGTCGAGGCCGCGCTGGCGGGCGATCTGCCGGGAGAAGTGCTGACCGCAGAGGAAGCCGTCGTCTACGACGCCGAGATC
GACGCTCATCTCGAAGCGCGGCTCGCGACCGACGACCACGTGGTTCGTCGTGCCTCGGCCGGGTTGTCCTCGGTGGTCGT
CGATGACGCCGGACAGCTCGTCGAACACCGCCCCGACGGGACGAGCGTCATCCTCGAGCAGTGA
ATGAGCACTGGTACGGACAAGGTGACCCGGCTGTCTGCTGCGTTGGTGACCGATGCGGCCCGGGAGGGCGCGCGAGAGCA
GCGGTCGGCGCGGCAGCAACTCGAACACTGGGCGCGTCTGGGGCGCAGCGTCTCGCAGCGCACCACCGCGTCGCGTCAGC
GGGTCGAGGCCGCGCTGGCGGGCGATCTGCCGGGAGAAGTGCTGACCGCAGAGGAAGCCGTCGTCTACGACGCCGAGATC
GACGCTCATCTCGAAGCGCGGCTCGCGACCGACGACCACGTGGTTCGTCGTGCCTCGGCCGGGTTGTCCTCGGTGGTCGT
CGATGACGCCGGACAGCTCGTCGAACACCGCCCCGACGGGACGAGCGTCATCCTCGAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|