Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 472890..473547 Replicon chromosome
Accession NZ_CP089403
Organism Klebsiella pasteurii strain Kox205

Toxin (Protein)


Gene name cptA Uniprot ID H3N294
Locus tag LUW96_RS02280 Protein ID WP_004124948.1
Coordinates 472890..473300 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag LUW96_RS02285 Protein ID WP_004124953.1
Coordinates 473281..473547 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW96_RS02260 (LUW96_02260) 468867..470600 - 1734 WP_004124937.1 single-stranded-DNA-specific exonuclease RecJ -
LUW96_RS02265 (LUW96_02265) 470606..471319 - 714 WP_049115165.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LUW96_RS02270 (LUW96_02270) 471342..472238 - 897 WP_049115164.1 site-specific tyrosine recombinase XerD -
LUW96_RS02275 (LUW96_02275) 472360..472881 + 522 WP_004124946.1 flavodoxin FldB -
LUW96_RS02280 (LUW96_02280) 472890..473300 - 411 WP_004124948.1 protein YgfX Toxin
LUW96_RS02285 (LUW96_02285) 473281..473547 - 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
LUW96_RS02290 (LUW96_02290) 473792..474775 + 984 WP_049122979.1 tRNA-modifying protein YgfZ -
LUW96_RS02295 (LUW96_02295) 474948..477746 + 2799 WP_004124960.1 transcriptional regulator DagR -
LUW96_RS02300 (LUW96_02300) 477866..478291 + 426 WP_004124962.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.88 Da        Isoelectric Point: 10.9455

>T228167 WP_004124948.1 NZ_CP089403:c473300-472890 [Klebsiella pasteurii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

>T228167 NZ_CP123381:c2917927-2917637 [Gordonia sp. SMJS1]
ATGAGCGACGCTCCGACAGACTCGTCCGCCCCGTACCGGGTTGAGGTCGCATCCCCAGCTCGACGCGACCTTCAACGACT
CCCATCCCGGATCGTCCACGCCGTCATCGAATTCATCTCCGGGCCGCTCGCCGAGAACCCCCACCGGCTTAGCAAGCCGC
TGCGCGACGACCTCGCAGACCTTCACAGCGCCCGCCGCGGCGATTATCGCATCCTGCTCCGCATCGACGACCCCAACCAC
ACCATCGTCATTGTCAGAATCGACCACCGAGCCCACGCCTACCGCACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT228167 WP_004124953.1 NZ_CP089403:c473547-473281 [Klebsiella pasteurii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228167 NZ_CP123381:c2918199-2917924 [Gordonia sp. SMJS1]
ATGACGACAGTGCCACTCGGTGAAGCTAAGGACAAGCTCTCCGCGCTGGTCGACAGCGCCGAGAGCACGCACGACATCAT
CACGATCACCAAGCACGGCAAACCCGCCGCGGTGCTGATGTCGGCCGACGACCTCGAATCGCTGCACGAGACGATCTACT
GGCTCTCACGCGCCGGCGTCCGCGACGACGTCGCTACCGCAGACGCCGAGTACGCGGCCGGTGAGACCGTCTCCATCGAC
GACCTGCGCGCCGAACACGGCATGCCGCCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3N294

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References