Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5144648..5146329 Replicon chromosome
Accession NZ_CP089385
Organism Klebsiella variicola subsp. variicola strain KPN692

Toxin (Protein)


Gene name mosT Uniprot ID A0A7H4S924
Locus tag LUX40_RS24735 Protein ID WP_012969143.1
Coordinates 5144648..5145565 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A0B7GCX3
Locus tag LUX40_RS24740 Protein ID WP_008807257.1
Coordinates 5145571..5146329 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX40_RS24715 (LUX40_24715) 5139954..5141474 + 1521 WP_008807253.1 sugar ABC transporter ATP-binding protein -
LUX40_RS24720 (LUX40_24720) 5141471..5142469 + 999 WP_004206363.1 ribose ABC transporter permease -
LUX40_RS24725 (LUX40_24725) 5142500..5143441 + 942 WP_012543155.1 ABC transporter substrate-binding protein -
LUX40_RS24730 (LUX40_24730) 5143516..5144523 + 1008 WP_023323480.1 carbohydrate kinase family protein -
LUX40_RS24735 (LUX40_24735) 5144648..5145565 - 918 WP_012969143.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LUX40_RS24740 (LUX40_24740) 5145571..5146329 - 759 WP_008807257.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LUX40_RS24745 (LUX40_24745) 5146414..5147142 - 729 WP_008807258.1 response regulator transcription factor -
LUX40_RS24750 (LUX40_24750) 5147415..5149562 + 2148 WP_077625405.1 formate dehydrogenase subunit alpha -
LUX40_RS24755 (LUX40_24755) 5149916..5150602 + 687 WP_016160120.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34721.11 Da        Isoelectric Point: 5.4707

>T228148 WP_012969143.1 NZ_CP089385:c5145565-5144648 [Klebsiella variicola subsp. variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T228148 NZ_CP123365:c2064136-2063981 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28653.01 Da        Isoelectric Point: 10.1988

>AT228148 WP_008807257.1 NZ_CP089385:c5146329-5145571 [Klebsiella variicola subsp. variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT228148 NZ_CP123365:2064148-2064206 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4S924

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7GCX3

References