Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4524714..4525394 Replicon chromosome
Accession NZ_CP089383
Organism Klebsiella pneumoniae strain KPN342

Toxin (Protein)


Gene name yeeV Uniprot ID A0A483NEU6
Locus tag LUX38_RS22115 Protein ID WP_004186789.1
Coordinates 4524714..4525034 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A483NFV3
Locus tag LUX38_RS22120 Protein ID WP_004186786.1
Coordinates 4525071..4525394 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX38_RS22090 (4520303) 4520303..4521436 + 1134 WP_004186798.1 HNH endonuclease signature motif containing protein -
LUX38_RS22095 (4521444) 4521444..4521953 + 510 WP_004186797.1 YrhA family protein -
LUX38_RS22100 (4522354) 4522354..4523304 - 951 WP_004186795.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LUX38_RS22105 (4523297) 4523297..4523692 - 396 WP_004186793.1 DUF6088 family protein -
LUX38_RS22110 (4523767) 4523767..4524600 - 834 WP_232410740.1 DUF4942 domain-containing protein -
LUX38_RS22115 (4524714) 4524714..4525034 - 321 WP_004186789.1 TA system toxin CbtA family protein Toxin
LUX38_RS22120 (4525071) 4525071..4525394 - 324 WP_004186786.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LUX38_RS22125 (4525407) 4525407..4525877 - 471 WP_004186785.1 DNA repair protein RadC -
LUX38_RS22130 (4525948) 4525948..4526769 - 822 WP_004186782.1 DUF932 domain-containing protein -
LUX38_RS22135 (4526879) 4526879..4527340 - 462 WP_019704405.1 IrmA family protein -
LUX38_RS22140 (4527458) 4527458..4528087 - 630 WP_004186778.1 hypothetical protein -
LUX38_RS22145 (4528093) 4528093..4528794 - 702 WP_004186776.1 WYL domain-containing protein -
LUX38_RS22150 (4529007) 4529007..4529882 - 876 WP_019704406.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4516268..4548124 31856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(11-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11982.64 Da        Isoelectric Point: 6.3221

>T228126 WP_004186789.1 NZ_CP089383:c4525034-4524714 [Klebsiella pneumoniae]
MHISTVPAKVPVSSRLSPVQVWQQLLTYLLGHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
SWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T228126 NZ_CP123300:756615-757475 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATCAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12005.80 Da        Isoelectric Point: 6.4664

>AT228126 WP_004186786.1 NZ_CP089383:c4525394-4525071 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGSFSPMHLQKIDLAFPLFVEQLEDMLHAGELNPHQQCQVK
IQLASLTCIADTRGSCGYVYISIYPKP

Download         Length: 324 bp

>AT228126 NZ_CP123300:756008-756622 [Mycoplasmopsis bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NEU6

Antitoxin

Source ID Structure
AlphaFold DB A0A483NFV3

References