228125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4522354..4523692 Replicon chromosome
Accession NZ_CP089383
Organism Klebsiella pneumoniae strain KPN342

Toxin (Protein)


Gene name sanaT Uniprot ID A0A483NH02
Locus tag LUX38_RS22100 Protein ID WP_004186795.1
Coordinates 4522354..4523304 (-) Length 317 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A1W6B2R8
Locus tag LUX38_RS22105 Protein ID WP_004186793.1
Coordinates 4523297..4523692 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX38_RS22080 (4517789) 4517789..4519030 - 1242 WP_004186803.1 hypothetical protein -
LUX38_RS22085 (4519561) 4519561..4519881 + 321 WP_004186800.1 hypothetical protein -
LUX38_RS22090 (4520303) 4520303..4521436 + 1134 WP_004186798.1 HNH endonuclease signature motif containing protein -
LUX38_RS22095 (4521444) 4521444..4521953 + 510 WP_004186797.1 YrhA family protein -
LUX38_RS22100 (4522354) 4522354..4523304 - 951 WP_004186795.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LUX38_RS22105 (4523297) 4523297..4523692 - 396 WP_004186793.1 DUF6088 family protein Antitoxin
LUX38_RS22110 (4523767) 4523767..4524600 - 834 WP_232410740.1 DUF4942 domain-containing protein -
LUX38_RS22115 (4524714) 4524714..4525034 - 321 WP_004186789.1 TA system toxin CbtA family protein -
LUX38_RS22120 (4525071) 4525071..4525394 - 324 WP_004186786.1 type IV toxin-antitoxin system YeeU family antitoxin -
LUX38_RS22125 (4525407) 4525407..4525877 - 471 WP_004186785.1 DNA repair protein RadC -
LUX38_RS22130 (4525948) 4525948..4526769 - 822 WP_004186782.1 DUF932 domain-containing protein -
LUX38_RS22135 (4526879) 4526879..4527340 - 462 WP_019704405.1 IrmA family protein -
LUX38_RS22140 (4527458) 4527458..4528087 - 630 WP_004186778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4516268..4548124 31856
- flank IS/Tn - - 4517112..4517369 257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-304)

Antitoxin

Protein of unknown function DUF6088

(7-114)


Sequences

Toxin        


Download         Length: 317 a.a.        Molecular weight: 36069.47 Da        Isoelectric Point: 4.6461

>T228125 WP_004186795.1 NZ_CP089383:c4523304-4522354 [Klebsiella pneumoniae]
MDDLTKLFPDVADALGIESVAIVEKDHYIVELLRLLQPLSFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVTGFSL
QYSRNQRKNIRKDIIKTITETIVASGMFSMDEEYPKVTRDENRYNEIPVRYPQEYVQIPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGAEVPVLKRFV
QECIEQDIQRYGAQYPEFCESPVEELKMGLEELASNPVYKERYLQFVTPMVFGESHVSWEEAYACFRITALDVIDA

Download         Length: 951 bp

>T228125 NZ_CP123299:c906857-905997 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATCAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14400.75 Da        Isoelectric Point: 11.0360

>AT228125 WP_004186793.1 NZ_CP089383:c4523692-4523297 [Klebsiella pneumoniae]
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELMKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSAAVMIE
ALERLKVDYRLAGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Download         Length: 396 bp

>AT228125 NZ_CP123299:c907464-906850 [Mycoplasmopsis bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NH02

Antitoxin

Source ID Structure
AlphaFold DB A0A1W6B2R8

References