228122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2537373..2538961 Replicon chromosome
Accession NZ_CP089383
Organism Klebsiella pneumoniae strain KPN342

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LUX38_RS12520 Protein ID WP_004213069.1
Coordinates 2537373..2538695 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LUX38_RS12525 Protein ID WP_004176198.1
Coordinates 2538695..2538961 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX38_RS12505 (2532429) 2532429..2534930 + 2502 WP_015958403.1 fimbria/pilus outer membrane usher protein -
LUX38_RS12510 (2534918) 2534918..2535922 + 1005 WP_048337093.1 fimbrial protein -
LUX38_RS12515 (2536064) 2536064..2537356 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LUX38_RS12520 (2537373) 2537373..2538695 - 1323 WP_004213069.1 type II toxin-antitoxin system HipA family toxin Toxin
LUX38_RS12525 (2538695) 2538695..2538961 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LUX38_RS12530 (2539347) 2539347..2539673 - 327 WP_004215084.1 hydroxyisourate hydrolase -
LUX38_RS12535 (2539670) 2539670..2540170 - 501 WP_004215086.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LUX38_RS12540 (2540148) 2540148..2541527 - 1380 WP_004215088.1 nucleobase:cation symporter-2 family protein -
LUX38_RS12545 (2541873) 2541873..2543027 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LUX38_RS12550 (2543008) 2543008..2543931 - 924 WP_064158859.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.5357

>T228122 WP_004213069.1 NZ_CP089383:c2538695-2537373 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T228122 NZ_CP123294:526992-527852 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATGAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT228122 WP_004176198.1 NZ_CP089383:c2538961-2538695 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT228122 NZ_CP123294:526385-526999 [Mycoplasmopsis bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References