Detailed information of TA system TA228113

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 777671..778328
• Replicon: chromosome
• Accession: NZ_CP089383
• Organism: Klebsiella pneumoniae strain KPN342

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: W8UCT0
• Locus tag: LUX38_RS03850
• Protein ID: WP_002916310.1
• Coordinates: 777918..778328 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LUX38_RS03845
• Protein ID: WP_232410788.1
• Coordinates: 777671..777937 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUX38_RS03820 (772879)	772879..774312	-	1434	WP_004185559.1	6-phospho-beta-glucosidase BglA	-
LUX38_RS03825 (774431)	774431..775159	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
LUX38_RS03830 (775209)	775209..775520	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
LUX38_RS03835 (775684)	775684..776343	+	660	WP_002916317.1	hemolysin III family protein	-
LUX38_RS03840 (776442)	776442..777425	-	984	WP_040181670.1	tRNA-modifying protein YgfZ	-
LUX38_RS03845 (777671)	777671..777937	+	267	WP_232410788.1	FAD assembly factor SdhE	Antitoxin
LUX38_RS03850 (777918)	777918..778328	+	411	WP_002916310.1	protein YgfX	Toxin
LUX38_RS03855 (778335)	778335..778856	-	522	WP_002916308.1	flavodoxin FldB	-
LUX38_RS03860 (778957)	778957..779853	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
LUX38_RS03865 (779876)	779876..780589	+	714	WP_004185548.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LUX38_RS03870 (780595)	780595..782328	+	1734	WP_004185546.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16049.85 Da
• Isoelectric Point: 11.4778

>T228113 WP_002916310.1 NZ_CP089383:777918-778328 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T228113 NZ_CP123283:c23615-23334 [Salmonella sp. SA14318]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10511.01 Da
• Isoelectric Point: 5.1116

>AT228113 WP_232410788.1 NZ_CP089383:777671-777937 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPTDAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT228113 NZ_CP123283:c23856-23605 [Salmonella sp. SA14318]
ATGAGCTATCAAATTCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Toxin

• AlphaFold DB: A0A0H3GSW7