Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 706659..707434 Replicon chromosome
Accession NZ_CP089383
Organism Klebsiella pneumoniae strain KPN342

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag LUX38_RS03490 Protein ID WP_004889762.1
Coordinates 706949..707434 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LUX38_RS03485 Protein ID WP_004150912.1
Coordinates 706659..706952 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX38_RS03465 (701869) 701869..702471 - 603 WP_015958984.1 short chain dehydrogenase -
LUX38_RS03470 (702569) 702569..703480 + 912 WP_021314148.1 LysR family transcriptional regulator -
LUX38_RS03475 (703481) 703481..704629 - 1149 WP_020316731.1 PLP-dependent aspartate aminotransferase family protein -
LUX38_RS03480 (704640) 704640..706016 - 1377 WP_004181304.1 cystathionine beta-synthase -
LUX38_RS03485 (706659) 706659..706952 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LUX38_RS03490 (706949) 706949..707434 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
LUX38_RS03495 (707613) 707613..708065 - 453 WP_080816334.1 hypothetical protein -
LUX38_RS03500 (708180) 708180..708399 - 220 Protein_686 hypothetical protein -
LUX38_RS03505 (708570) 708570..710855 - 2286 WP_094326278.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T228112 WP_004889762.1 NZ_CP089383:706949-707434 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

>T228112 NZ_CP123282:4519295-4519606 [Salmonella sp. SA14318]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT228112 WP_004150912.1 NZ_CP089383:706659-706952 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT228112 NZ_CP123282:4519603-4520049 [Salmonella sp. SA14318]
ATGAGAACTCATCGCCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References