Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2507724..2508335 Replicon chromosome
Accession NC_010577
Organism Xylella fastidiosa M23

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag XFASM23_RS11140 Protein ID WP_011098375.1
Coordinates 2508036..2508335 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag XFASM23_RS11135 Protein ID WP_004085003.1
Coordinates 2507724..2508032 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFASM23_RS11105 2504294..2505055 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
XFASM23_RS11130 2506247..2507650 + 1404 WP_011098374.1 hypothetical protein -
XFASM23_RS11135 2507724..2508032 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
XFASM23_RS11140 2508036..2508335 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFASM23_RS11145 2508423..2508968 + 546 WP_011098376.1 hypothetical protein -
XFASM23_RS13135 2508980..2509123 + 144 WP_155115087.1 hypothetical protein -
XFASM23_RS11150 2509276..2509656 - 381 WP_004089371.1 DUF596 domain-containing protein -
XFASM23_RS11155 2509661..2510791 - 1131 WP_012382788.1 DUF769 domain-containing protein -
XFASM23_RS11160 2511099..2511479 - 381 WP_004087391.1 DUF596 domain-containing protein -
XFASM23_RS11165 2511491..2513065 - 1575 Protein_2175 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2458491..2508785 50294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T22811 WP_011098375.1 NC_010577:c2508335-2508036 [Xylella fastidiosa M23]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T22811 NC_010577:c2508335-2508036 [Xylella fastidiosa M23]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT22811 WP_004085003.1 NC_010577:c2508032-2507724 [Xylella fastidiosa M23]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT22811 NC_010577:c2508032-2507724 [Xylella fastidiosa M23]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References