Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 106267..107006 Replicon plasmid pKP062-2
Accession NZ_CP089327
Organism Klebsiella pneumoniae strain KP062

Toxin (Protein)


Gene name tacT Uniprot ID J6I5J9
Locus tag LUX41_RS27245 Protein ID WP_009653238.1
Coordinates 106521..107006 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID J5VA20
Locus tag LUX41_RS27240 Protein ID WP_009653219.1
Coordinates 106267..106533 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX41_RS27210 (LUX41_27165) 101869..102627 - 759 WP_023303135.1 hypothetical protein -
LUX41_RS27215 (LUX41_27170) 102681..103601 - 921 WP_009651631.1 hypothetical protein -
LUX41_RS27220 (LUX41_27175) 103665..104036 - 372 WP_029602876.1 hypothetical protein -
LUX41_RS27225 (LUX41_27180) 104177..104866 - 690 WP_009654088.1 hypothetical protein -
LUX41_RS27230 (LUX41_27185) 104880..105617 - 738 WP_009654087.1 HupE/UreJ family protein -
LUX41_RS27235 (LUX41_27190) 105662..106027 - 366 WP_029602878.1 hypothetical protein -
LUX41_RS27240 (LUX41_27195) 106267..106533 + 267 WP_009653219.1 DUF1778 domain-containing protein Antitoxin
LUX41_RS27245 (LUX41_27200) 106521..107006 + 486 WP_009653238.1 GNAT family N-acetyltransferase Toxin
LUX41_RS27250 (LUX41_27205) 107306..108379 - 1074 WP_048270288.1 IS481 family transposase -
LUX41_RS27255 (LUX41_27210) 108440..108532 + 93 Protein_114 Hok/Gef family protein -
LUX41_RS27260 (LUX41_27215) 108496..108597 + 102 Protein_115 DUF5431 family protein -
LUX41_RS27265 (LUX41_27220) 108762..109247 - 486 WP_020277937.1 hypothetical protein -
LUX41_RS27270 (LUX41_27225) 109437..109709 + 273 WP_023280873.1 hypothetical protein -
LUX41_RS27275 (LUX41_27230) 109706..110056 + 351 WP_020277938.1 hypothetical protein -
LUX41_RS27280 (LUX41_27235) 110573..110953 + 381 WP_015632488.1 hypothetical protein -
LUX41_RS27285 (LUX41_27240) 111019..111366 + 348 WP_020316654.1 hypothetical protein -
LUX41_RS27290 (LUX41_27245) 111454..111684 + 231 WP_020805755.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..153468 153468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-150)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.9000

>T228108 WP_009653238.1 NZ_CP089327:106521-107006 [Klebsiella pneumoniae]
VGYVTSPEPLSSFHQVAEFISGEAVLDDWLKQRSLKNQATGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCFRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQSQPRTLFLRLP
Q

Download         Length: 486 bp

>T228108 NZ_CP123282:c4011078-4010770 [Salmonella sp. SA14318]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATAGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAACGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.58 Da        Isoelectric Point: 4.4128

>AT228108 WP_009653219.1 NZ_CP089327:106267-106533 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDEQYAEFIDMIDAPVADDPAIEKLL
ARKPQWDM

Download         Length: 267 bp

>AT228108 NZ_CP123282:c4011320-4011081 [Salmonella sp. SA14318]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACGGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142I4R1

Antitoxin

Source ID Structure
AlphaFold DB A0A142I4R0

References