Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 62991..63516 Replicon plasmid pKP062-2
Accession NZ_CP089327
Organism Klebsiella pneumoniae strain KP062

Toxin (Protein)


Gene name ccdB Uniprot ID W8UQV6
Locus tag LUX41_RS26990 Protein ID WP_001568026.1
Coordinates 63211..63516 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag LUX41_RS26985 Protein ID WP_001568025.1
Coordinates 62991..63209 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX41_RS26975 (LUX41_26930) 60672..61700 - 1029 WP_001568023.1 Abi family protein -
LUX41_RS26980 (LUX41_26935) 61841..62410 - 570 WP_016162066.1 hypothetical protein -
LUX41_RS26985 (LUX41_26940) 62991..63209 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LUX41_RS26990 (LUX41_26945) 63211..63516 + 306 WP_001568026.1 type II toxin-antitoxin system toxin CcdB Toxin
LUX41_RS26995 (LUX41_26950) 63685..64080 + 396 WP_072158608.1 hypothetical protein -
LUX41_RS27000 (LUX41_26955) 64107..64430 + 324 WP_022644730.1 hypothetical protein -
LUX41_RS27005 (LUX41_26960) 64427..65443 + 1017 WP_020315256.1 hypothetical protein -
LUX41_RS27010 (LUX41_26965) 65778..67046 - 1269 WP_019705993.1 ISL3-like element ISKpn25 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..153468 153468
- flank IS/Tn - - 65778..67046 1268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11645.32 Da        Isoelectric Point: 5.6919

>T228107 WP_001568026.1 NZ_CP089327:63211-63516 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T228107 NZ_CP123282:3550677-3550922 [Salmonella sp. SA14318]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT228107 WP_001568025.1 NZ_CP089327:62991-63209 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT228107 NZ_CP123282:c3550886-3550520 [Salmonella sp. SA14318]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACTGCGCCCCCCTCTCCCCG
GCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EZN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References