Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 65602..66512 Replicon plasmid pKP062-1
Accession NZ_CP089326
Organism Klebsiella pneumoniae strain KP062

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag LUX41_RS26115 Protein ID WP_004144067.1
Coordinates 65602..66072 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag LUX41_RS26120 Protein ID WP_023287184.1
Coordinates 66069..66512 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX41_RS26085 (LUX41_26050) 61303..62121 + 819 Protein_61 response regulator -
LUX41_RS26090 (LUX41_26055) 62128..62682 + 555 Protein_62 transposase -
LUX41_RS26095 (LUX41_26060) 62768..62944 + 177 Protein_63 transposase -
LUX41_RS26105 (LUX41_26070) 64333..64518 - 186 Protein_65 transposase -
LUX41_RS26110 (LUX41_26075) 64520..65515 - 996 WP_077254794.1 IS5 family transposase -
LUX41_RS26115 (LUX41_26080) 65602..66072 - 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
LUX41_RS26120 (LUX41_26085) 66069..66512 - 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
LUX41_RS26125 (LUX41_26090) 66613..67704 - 1092 Protein_69 translesion error-prone DNA polymerase V subunit UmuC -
LUX41_RS26130 (LUX41_26095) 67764..68732 - 969 WP_016809156.1 IS5-like element IS903B family transposase -
LUX41_RS26135 (LUX41_26100) 68874..71102 - 2229 WP_032430744.1 ThiF family adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..172904 172904
- inside IScluster/Tn - - 62308..68732 6424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T228106 WP_004144067.1 NZ_CP089326:c66072-65602 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T228106 NZ_CP123282:3360288-3360506 [Salmonella sp. SA14318]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT228106 WP_023287184.1 NZ_CP089326:c66512-66069 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT228106 NZ_CP123282:3359886-3360260 [Salmonella sp. SA14318]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References