Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4723474..4723990 Replicon chromosome
Accession NZ_CP089325
Organism Klebsiella pneumoniae strain KP062

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LUX41_RS23150 Protein ID WP_002886902.1
Coordinates 4723474..4723758 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LUX41_RS23155 Protein ID WP_002886901.1
Coordinates 4723748..4723990 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX41_RS23125 (4718891) 4718891..4719154 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
LUX41_RS23130 (4719284) 4719284..4719457 + 174 WP_032410138.1 hypothetical protein -
LUX41_RS23135 (4719460) 4719460..4720203 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
LUX41_RS23140 (4720560) 4720560..4722698 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LUX41_RS23145 (4723006) 4723006..4723470 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUX41_RS23150 (4723474) 4723474..4723758 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUX41_RS23155 (4723748) 4723748..4723990 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LUX41_RS23160 (4724068) 4724068..4725978 - 1911 WP_004152270.1 PRD domain-containing protein -
LUX41_RS23165 (4726001) 4726001..4727155 - 1155 WP_002886900.1 lactonase family protein -
LUX41_RS23170 (4727222) 4727222..4727962 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T228101 WP_002886902.1 NZ_CP089325:c4723758-4723474 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T228101 NZ_CP123282:319426-319794 [Salmonella sp. SA14318]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTATTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT228101 WP_002886901.1 NZ_CP089325:c4723990-4723748 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT228101 NZ_CP123282:319208-319429 [Salmonella sp. SA14318]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGATCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References