Detailed information of TA system TA228100

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4642310..4643002
• Replicon: chromosome
• Accession: NZ_CP089325
• Organism: Klebsiella pneumoniae strain KP062

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: LUX41_RS22800
• Protein ID: WP_071603219.1
• Coordinates: 4642310..4642651 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: LUX41_RS22805
• Protein ID: WP_040189932.1
• Coordinates: 4642676..4643002 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUX41_RS22775 (4638218)	4638218..4639672	-	1455	WP_074184809.1	serine protease	-
LUX41_RS22780 (4639860)	4639860..4640657	-	798	WP_038806919.1	helix-turn-helix transcriptional regulator	-
LUX41_RS22785 (4640758)	4640758..4641033	-	276	Protein_4467	type II toxin-antitoxin system RelE/ParE family toxin	-
LUX41_RS22790 (4641037)	4641037..4641285	-	249	WP_038806909.1	ribbon-helix-helix domain-containing protein	-
LUX41_RS22795 (4641362)	4641362..4642195	-	834	WP_038806910.1	DUF4942 domain-containing protein	-
LUX41_RS22800 (4642310)	4642310..4642651	-	342	WP_071603219.1	TA system toxin CbtA family protein	Toxin
LUX41_RS22805 (4642676)	4642676..4643002	-	327	WP_040189932.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LUX41_RS22810 (4643016)	4643016..4643492	-	477	WP_038806912.1	DNA repair protein RadC	-
LUX41_RS22815 (4643503)	4643503..4643949	-	447	WP_038806913.1	antirestriction protein	-
LUX41_RS22820 (4644173)	4644173..4644862	-	690	WP_038806914.1	hypothetical protein	-
LUX41_RS22825 (4645182)	4645182..4645535	+	354	WP_038806915.1	hypothetical protein	-
LUX41_RS22830 (4645572)	4645572..4646462	-	891	WP_038806917.1	YfjP family GTPase	-
LUX41_RS22835 (4646560)	4646560..4647825	+	1266	WP_038806918.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4625651..4665192	39541

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (8-107)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12762.63 Da
• Isoelectric Point: 7.8846

>T228100 WP_071603219.1 NZ_CP089325:c4642651-4642310 [Klebsiella pneumoniae]
MKTIPATTQRAAKSCPSPVAFWQMPLTRLLEQHYGLTLNDTPFSDETAIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQVTGLLRQSPHPSIR

Nucleotide

• Length: 342 bp

>T228100 NZ_CP123282:203763-204248 [Salmonella sp. SA14318]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCTGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12333.06 Da
• Isoelectric Point: 6.9560

>AT228100 WP_040189932.1 NZ_CP089325:c4643002-4642676 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDAECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Nucleotide

• Length: 327 bp

>AT228100 NZ_CP123282:203488-203775 [Salmonella sp. SA14318]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA