Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1581780..1582366 Replicon chromosome
Accession NC_010577
Organism Xylella fastidiosa M23

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag XFASM23_RS12260 Protein ID WP_004089517.1
Coordinates 1582112..1582366 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag XFASM23_RS07135 Protein ID WP_004085025.1
Coordinates 1581780..1582115 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFASM23_RS07105 1577379..1578233 - 855 WP_011098055.1 iron-sulfur cluster carrier protein ApbC -
XFASM23_RS07110 1578725..1579498 + 774 WP_004089528.1 3-deoxy-manno-octulosonate cytidylyltransferase -
XFASM23_RS07115 1579495..1579959 + 465 WP_011098056.1 low molecular weight phosphotyrosine protein phosphatase -
XFASM23_RS07120 1579946..1580659 - 714 WP_011098057.1 site-specific DNA-methyltransferase -
XFASM23_RS07125 1581010..1581291 + 282 WP_011098058.1 type II toxin-antitoxin system RelE/ParE family toxin -
XFASM23_RS07130 1581301..1581600 + 300 WP_004089519.1 HigA family addiction module antidote protein -
XFASM23_RS07135 1581780..1582115 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
XFASM23_RS12260 1582112..1582366 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
XFASM23_RS07140 1582419..1583117 - 699 WP_011098059.1 hypothetical protein -
XFASM23_RS07145 1583246..1583707 - 462 WP_011098060.1 hypothetical protein -
XFASM23_RS07150 1583704..1584468 - 765 WP_004090689.1 hypothetical protein -
XFASM23_RS07155 1584374..1585480 - 1107 WP_012382665.1 YdaU family protein -
XFASM23_RS12265 1585477..1585776 - 300 WP_080513037.1 hypothetical protein -
XFASM23_RS07160 1585775..1586252 + 478 Protein_1400 conjugal transfer protein -
XFASM23_RS07165 1586258..1586863 + 606 WP_004091108.1 conjugal transfer protein TrbN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T22810 WP_004089517.1 NC_010577:c1582366-1582112 [Xylella fastidiosa M23]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T22810 NC_010577:c1582366-1582112 [Xylella fastidiosa M23]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGACTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCTCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT22810 WP_004085025.1 NC_010577:c1582115-1581780 [Xylella fastidiosa M23]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT22810 NC_010577:c1582115-1581780 [Xylella fastidiosa M23]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGATAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References