Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 840626..841283 Replicon chromosome
Accession NZ_CP089325
Organism Klebsiella pneumoniae strain KP062

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LUX41_RS04220 Protein ID WP_002916310.1
Coordinates 840873..841283 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LUX41_RS04215 Protein ID WP_002916312.1
Coordinates 840626..840892 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX41_RS04190 (835782) 835782..837215 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LUX41_RS04195 (837334) 837334..838062 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LUX41_RS04200 (838112) 838112..838423 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LUX41_RS04205 (838587) 838587..839246 + 660 WP_002916317.1 hemolysin III family protein -
LUX41_RS04210 (839397) 839397..840380 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
LUX41_RS04215 (840626) 840626..840892 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LUX41_RS04220 (840873) 840873..841283 + 411 WP_002916310.1 protein YgfX Toxin
LUX41_RS04225 (841290) 841290..841811 - 522 WP_004144730.1 flavodoxin FldB -
LUX41_RS04230 (841912) 841912..842808 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LUX41_RS04235 (842831) 842831..843544 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LUX41_RS04240 (843550) 843550..845283 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T228088 WP_002916310.1 NZ_CP089325:840873-841283 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T228088 NZ_CP123280:c2406817-2406530 [Salmonella sp. SA17155]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT228088 WP_002916312.1 NZ_CP089325:840626-840892 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228088 NZ_CP123280:c2406543-2406241 [Salmonella sp. SA17155]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References