228082

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 221803..222332 Replicon chromosome
Accession NZ_CP089319
Organism Enterococcus faecium strain NMVRE-001

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag LUB18_RS01100 Protein ID WP_002296560.1
Coordinates 222066..222332 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag LUB18_RS01095 Protein ID WP_002296559.1
Coordinates 221803..222066 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUB18_RS01085 (LUB18_01085) 219177..221000 + 1824 WP_002294202.1 APC family permease -
LUB18_RS01090 (LUB18_01090) 221142..221327 - 186 WP_002296558.1 transcriptional regulator -
LUB18_RS01095 (LUB18_01095) 221803..222066 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LUB18_RS01100 (LUB18_01100) 222066..222332 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
LUB18_RS01105 (LUB18_01105) 222533..223021 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
LUB18_RS01110 (LUB18_01110) 223562..224233 - 672 WP_002302663.1 ABC transporter permease -
LUB18_RS01115 (LUB18_01115) 224230..225147 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
LUB18_RS01120 (LUB18_01120) 225144..225785 - 642 WP_002293405.1 ABC transporter permease -
LUB18_RS01125 (LUB18_01125) 225789..226370 - 582 Protein_224 CBS domain-containing protein -
LUB18_RS01130 (LUB18_01130) 226528..226932 + 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T228082 WP_002296560.1 NZ_CP089319:222066-222332 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T228082 NZ_CP123280:330709-330812 [Salmonella sp. SA17155]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT228082 WP_002296559.1 NZ_CP089319:221803-222066 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT228082 NZ_CP123280:c330813-330669 [Salmonella sp. SA17155]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References