Detailed information of TA system TA228080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3864988..3865687
• Replicon: chromosome
• Accession: NZ_CP089317
• Organism: Proteus mirabilis strain PM1162

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LUA10_RS18340
• Protein ID: WP_017628658.1
• Coordinates: 3864988..3865374 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: LUA10_RS18345
• Protein ID: WP_004246828.1
• Coordinates: 3865367..3865687 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUA10_RS18325 (LUA10_18325)	3861007..3861588	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
LUA10_RS18330 (LUA10_18330)	3861839..3862744	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
LUA10_RS18335 (LUA10_18335)	3862754..3864826	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
LUA10_RS18340 (LUA10_18340)	3864988..3865374	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LUA10_RS18345 (LUA10_18345)	3865367..3865687	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
LUA10_RS18350 (LUA10_18350)	3865736..3866170	-	435	WP_004246827.1	hypothetical protein	-
LUA10_RS18355 (LUA10_18355)	3866163..3867047	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
LUA10_RS18360 (LUA10_18360)	3867262..3868548	-	1287	WP_063073863.1	DUF3748 domain-containing protein	-
LUA10_RS18365 (LUA10_18365)	3868685..3869302	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
LUA10_RS18370 (LUA10_18370)	3869603..3870226	+	624	WP_004246821.1	guanylate kinase	-
LUA10_RS18375 (LUA10_18375)	3870281..3870556	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T228080 WP_017628658.1 NZ_CP089317:3864988-3865374 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T228080 NZ_CP089317:3864988-3865374 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT228080 WP_004246828.1 NZ_CP089317:3865367-3865687 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT228080 NZ_CP089317:3865367-3865687 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97