Detailed information of TA system TA022808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1307773..1308304
• Replicon: chromosome
• Accession: NC_010577
• Organism: Xylella fastidiosa M23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: XFASM23_RS05815
• Protein ID: WP_004090909.1
• Coordinates: 1308023..1308304 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: XFASM23_RS05810
• Protein ID: WP_004090907.1
• Coordinates: 1307773..1308036 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFASM23_RS05785	1302999..1304177	-	1179	WP_011097931.1	phage tail sheath family protein	-
XFASM23_RS05790	1304242..1305834	-	1593	WP_012382617.1	tail fiber domain-containing protein	-
XFASM23_RS05795	1305842..1306399	-	558	WP_011097610.1	phage tail protein I	-
XFASM23_RS05800	1306392..1307285	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
XFASM23_RS05805	1307285..1307623	-	339	WP_004090694.1	GPW/gp25 family protein	-
XFASM23_RS05810	1307773..1308036	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XFASM23_RS05815	1308023..1308304	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
XFASM23_RS05820	1308341..1308928	-	588	WP_011097612.1	phage baseplate assembly protein V	-
XFASM23_RS05825	1308925..1309467	-	543	WP_011097613.1	hypothetical protein	-
XFASM23_RS05830	1309443..1309964	-	522	WP_011097614.1	hypothetical protein	-
XFASM23_RS05835	1309961..1310284	-	324	WP_012382618.1	hypothetical protein	-
XFASM23_RS05840	1310284..1310544	-	261	WP_012382619.1	hypothetical protein	-
XFASM23_RS05845	1310562..1312436	-	1875	WP_012382620.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1294360..1341082	46722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T22808 WP_004090909.1 NC_010577:1308023-1308304 [Xylella fastidiosa M23]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T22808 NC_010577:1308023-1308304 [Xylella fastidiosa M23]
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTGATACACGTCTTGGAAGCCTTGACCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT22808 WP_004090907.1 NC_010577:1307773-1308036 [Xylella fastidiosa M23]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT22808 NC_010577:1307773-1308036 [Xylella fastidiosa M23]
ATGTCTGCAAACGCAGTTGTCCGTGCCCGCGTTGACGCGCACATCAAAGAAGAAGCATCAACCGTGCTGGCGACGATGGG
CCTAAGCGTGTCTGATGCGTTCCGTATGATGCTGACCCGCATTGCCCGCGAGAAGGCGCTGCCGTTCGAGCCGCTGGTGC
CGAACGAAACTACCATCGCAGCCATGCGTGAAGCCCGTGCTGGTCACCTCAAGAGCTTTGATAGTATTGAGGCGCTCATG
GCGGACTTGCATGCGGAGGATTAG

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2