Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 3738424..3738971 Replicon chromosome
Accession NZ_CP089317
Organism Proteus mirabilis strain PM1162

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LUA10_RS17785 Protein ID WP_244449344.1
Coordinates 3738693..3738971 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E2GHF7
Locus tag LUA10_RS17780 Protein ID WP_012881119.1
Coordinates 3738424..3738693 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUA10_RS17765 (LUA10_17765) 3734578..3735432 - 855 WP_004250107.1 4-hydroxybenzoate octaprenyltransferase -
LUA10_RS17770 (LUA10_17770) 3735461..3735970 - 510 WP_004245914.1 chorismate lyase -
LUA10_RS17775 (LUA10_17775) 3736192..3737838 - 1647 WP_004249156.1 glucose-6-phosphate isomerase -
LUA10_RS17780 (LUA10_17780) 3738424..3738693 + 270 WP_012881119.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
LUA10_RS17785 (LUA10_17785) 3738693..3738971 + 279 WP_244449344.1 type II toxin-antitoxin system toxin YacB Toxin
LUA10_RS17790 (LUA10_17790) 3739017..3739865 + 849 WP_012881117.1 3'-5' exonuclease -
LUA10_RS17795 (LUA10_17795) 3739982..3740464 + 483 WP_001311056.1 hypothetical protein -
LUA10_RS17800 (LUA10_17800) 3740499..3741521 - 1023 Protein_3463 maltoporin LamB -
LUA10_RS17805 (LUA10_17805) 3741570..3741977 - 408 Protein_3464 IS5-like element IS903B family transposase -
LUA10_RS17810 (LUA10_17810) 3742057..3742932 - 876 WP_001617865.1 extended-spectrum class A beta-lactamase CTX-M-14 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn blaCTX-M-14 - 3742057..3744444 2387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10744.34 Da        Isoelectric Point: 8.4615

>T228079 WP_244449344.1 NZ_CP089317:3738693-3738971 [Proteus mirabilis]
MEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T228079 NZ_CP123267:c96157-96008 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10206.54 Da        Isoelectric Point: 8.8735

>AT228079 WP_012881119.1 NZ_CP089317:3738424-3738693 [Proteus mirabilis]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK

Download         Length: 270 bp

>AT228079 NZ_CP123267:96201-96262 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y1YSD8

References