Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3496120..3496774 Replicon chromosome
Accession NZ_CP089316
Organism Citrobacter portucalensis strain K218

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LT989_RS17140 Protein ID WP_126956620.1
Coordinates 3496120..3496527 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag LT989_RS17145 Protein ID WP_126956618.1
Coordinates 3496508..3496774 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT989_RS17120 (3492011) 3492011..3493744 - 1734 WP_126956622.1 single-stranded-DNA-specific exonuclease RecJ -
LT989_RS17125 (3493750) 3493750..3494463 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LT989_RS17130 (3494487) 3494487..3495383 - 897 WP_003825519.1 site-specific tyrosine recombinase XerD -
LT989_RS17135 (3495497) 3495497..3496018 + 522 WP_003825517.1 flavodoxin FldB -
LT989_RS17140 (3496120) 3496120..3496527 - 408 WP_126956620.1 protein YgfX Toxin
LT989_RS17145 (3496508) 3496508..3496774 - 267 WP_126956618.1 FAD assembly factor SdhE Antitoxin
LT989_RS17150 (3497032) 3497032..3498015 + 984 WP_126956615.1 tRNA-modifying protein YgfZ -
LT989_RS17155 (3498147) 3498147..3498809 - 663 WP_063940912.1 hemolysin III family protein -
LT989_RS17160 (3498973) 3498973..3499284 - 312 WP_048225466.1 N(4)-acetylcytidine aminohydrolase -
LT989_RS17165 (3499337) 3499337..3500065 + 729 WP_008785744.1 MurR/RpiR family transcriptional regulator -
LT989_RS17170 (3500186) 3500186..3501619 + 1434 WP_126956613.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15912.79 Da        Isoelectric Point: 11.3523

>T228073 WP_126956620.1 NZ_CP089316:c3496527-3496120 [Citrobacter portucalensis]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKTKQG

Download         Length: 408 bp

>T228073 NZ_CP123266:3813595-3813873 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10601.11 Da        Isoelectric Point: 5.1599

>AT228073 WP_126956618.1 NZ_CP089316:c3496774-3496508 [Citrobacter portucalensis]
MDINNKARIHWACRRGMRELDISIMPFFEHDYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228073 NZ_CP123266:3813332-3813592 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References