Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/Fic(toxin) |
| Location | 1216901..1217697 | Replicon | chromosome |
| Accession | NC_010577 | ||
| Organism | Xylella fastidiosa M23 | ||
Toxin (Protein)
| Gene name | VbhT | Uniprot ID | Q87CQ8 |
| Locus tag | XFASM23_RS05330 | Protein ID | WP_004088112.1 |
| Coordinates | 1216901..1217512 (-) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | VbhA | Uniprot ID | B2I551 |
| Locus tag | XFASM23_RS05335 | Protein ID | WP_004088114.1 |
| Coordinates | 1217509..1217697 (-) | Length | 63 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XFASM23_RS05290 | 1212356..1213243 | - | 888 | WP_012382597.1 | YdaU family protein | - |
| XFASM23_RS05295 | 1213240..1214028 | - | 789 | WP_011097897.1 | Bro-N domain-containing protein | - |
| XFASM23_RS05300 | 1214025..1214657 | - | 633 | WP_004088094.1 | Bro-N domain-containing protein | - |
| XFASM23_RS12105 | 1214654..1214938 | - | 285 | WP_004088096.1 | hypothetical protein | - |
| XFASM23_RS05305 | 1214935..1215183 | - | 249 | WP_011097898.1 | hypothetical protein | - |
| XFASM23_RS05310 | 1215180..1215368 | - | 189 | WP_004088102.1 | hypothetical protein | - |
| XFASM23_RS12955 | 1215396..1215587 | - | 192 | WP_004088104.1 | hypothetical protein | - |
| XFASM23_RS05320 | 1215846..1216091 | - | 246 | WP_004088108.1 | hypothetical protein | - |
| XFASM23_RS05325 | 1216176..1216850 | + | 675 | WP_012382600.1 | helix-turn-helix transcriptional regulator | - |
| XFASM23_RS05330 | 1216901..1217512 | - | 612 | WP_004088112.1 | Fic/DOC family protein | Toxin |
| XFASM23_RS05335 | 1217509..1217697 | - | 189 | WP_004088114.1 | antitoxin VbhA family protein | Antitoxin |
| XFASM23_RS05345 | 1218089..1218625 | + | 537 | WP_012382601.1 | hypothetical protein | - |
| XFASM23_RS05350 | 1218622..1219035 | + | 414 | WP_004088056.1 | DUF1566 domain-containing protein | - |
| XFASM23_RS05355 | 1219032..1219433 | + | 402 | WP_004088054.1 | hypothetical protein | - |
| XFASM23_RS12960 | 1219430..1219579 | + | 150 | WP_012382602.1 | hypothetical protein | - |
| XFASM23_RS12110 | 1219665..1219943 | + | 279 | WP_004088050.1 | hypothetical protein | - |
| XFASM23_RS05360 | 1219966..1220157 | + | 192 | WP_012382603.1 | hypothetical protein | - |
| XFASM23_RS05365 | 1220178..1220522 | + | 345 | WP_004088346.1 | hypothetical protein | - |
| XFASM23_RS05370 | 1220562..1221383 | + | 822 | WP_004088345.1 | DUF2303 family protein | - |
| XFASM23_RS05375 | 1221399..1222325 | + | 927 | WP_004088344.1 | phage recombination protein Bet | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1203998..1227447 | 23449 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 22832.60 Da Isoelectric Point: 5.1271
>T22807 WP_004088112.1 NC_010577:c1217512-1216901 [Xylella fastidiosa M23]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
Download Length: 612 bp
>T22807 NC_010577:c1217512-1216901 [Xylella fastidiosa M23]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGGGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGTCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAAGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGTGGATTGGC
TAGTATCATCCGCGAAGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGGGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGTCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAAGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGTGGATTGGC
TAGTATCATCCGCGAAGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA
Antitoxin
Download Length: 63 a.a. Molecular weight: 6837.77 Da Isoelectric Point: 4.9859
>AT22807 WP_004088114.1 NC_010577:c1217697-1217509 [Xylella fastidiosa M23]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
Download Length: 189 bp
>AT22807 NC_010577:c1217697-1217509 [Xylella fastidiosa M23]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATTGCATGA
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATTGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|