Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 544759..545379 Replicon chromosome
Accession NZ_CP089316
Organism Citrobacter portucalensis strain K218

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LT989_RS02660 Protein ID WP_002892050.1
Coordinates 544759..544977 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag LT989_RS02665 Protein ID WP_003021733.1
Coordinates 545005..545379 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT989_RS02625 (540114) 540114..540746 + 633 WP_232397817.1 hypothetical protein -
LT989_RS02630 (540811) 540811..541164 + 354 WP_003831033.1 DUF1428 family protein -
LT989_RS02635 (541216) 541216..542769 - 1554 WP_003831035.1 EAL domain-containing protein -
LT989_RS02640 (542958) 542958..543218 + 261 WP_008783961.1 type B 50S ribosomal protein L31 -
LT989_RS02645 (543220) 543220..543360 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
LT989_RS02650 (543439) 543439..543909 - 471 WP_063941318.1 YlaC family protein -
LT989_RS02655 (544026) 544026..544577 - 552 WP_126955914.1 maltose O-acetyltransferase -
LT989_RS02660 (544759) 544759..544977 - 219 WP_002892050.1 HHA domain-containing protein Toxin
LT989_RS02665 (545005) 545005..545379 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
LT989_RS02670 (545868) 545868..549017 - 3150 WP_063941319.1 efflux RND transporter permease AcrB -
LT989_RS02675 (549040) 549040..550233 - 1194 WP_003831044.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T228061 WP_002892050.1 NZ_CP089316:c544977-544759 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T228061 NZ_CP123266:c781641-781264 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCTGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT228061 WP_003021733.1 NZ_CP089316:c545379-545005 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT228061 NZ_CP123266:c782099-781731 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References