Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 5393050..5393854 | Replicon | chromosome |
| Accession | NZ_CP089315 | ||
| Organism | Klebsiella michiganensis strain K92 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A486SQP3 |
| Locus tag | LT984_RS25705 | Protein ID | WP_040217122.1 |
| Coordinates | 5393050..5393439 (-) | Length | 130 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7H4M120 |
| Locus tag | LT984_RS25710 | Protein ID | WP_014837280.1 |
| Coordinates | 5393495..5393854 (-) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LT984_RS25675 (LT984_25675) | 5388092..5388886 | + | 795 | WP_042933970.1 | DNA/RNA non-specific endonuclease | - |
| LT984_RS25680 (LT984_25680) | 5389176..5389499 | + | 324 | WP_014837285.1 | endoribonuclease SymE | - |
| LT984_RS25685 (LT984_25685) | 5389658..5390092 | + | 435 | WP_004098173.1 | VOC family protein | - |
| LT984_RS25690 (LT984_25690) | 5390258..5391001 | + | 744 | WP_014837284.1 | hypothetical protein | - |
| LT984_RS25695 (LT984_25695) | 5391179..5391976 | - | 798 | WP_014837283.1 | helix-turn-helix transcriptional regulator | - |
| LT984_RS25700 (LT984_25700) | 5392118..5392963 | - | 846 | WP_014837282.1 | DUF4942 domain-containing protein | - |
| LT984_RS25705 (LT984_25705) | 5393050..5393439 | - | 390 | WP_040217122.1 | TA system toxin CbtA family protein | Toxin |
| LT984_RS25710 (LT984_25710) | 5393495..5393854 | - | 360 | WP_014837280.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LT984_RS25715 (LT984_25715) | 5393879..5394100 | - | 222 | WP_014837279.1 | DUF987 domain-containing protein | - |
| LT984_RS25720 (LT984_25720) | 5394114..5394593 | - | 480 | WP_014837278.1 | DNA repair protein RadC | - |
| LT984_RS25725 (LT984_25725) | 5394605..5395048 | - | 444 | WP_014837277.1 | antirestriction protein | - |
| LT984_RS25730 (LT984_25730) | 5395128..5395358 | - | 231 | WP_014837276.1 | DUF905 domain-containing protein | - |
| LT984_RS25735 (LT984_25735) | 5395382..5396206 | - | 825 | WP_040217125.1 | DUF932 domain-containing protein | - |
| LT984_RS25740 (LT984_25740) | 5396746..5397378 | + | 633 | WP_071886307.1 | inovirus Gp2 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 5389658..5428944 | 39286 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 130 a.a. Molecular weight: 14477.57 Da Isoelectric Point: 8.9843
>T228059 WP_040217122.1 NZ_CP089315:c5393439-5393050 [Klebsiella michiganensis]
MQTKSPPFMRAASSRPSPVGVWQTLLTCLLEHHYGLTLNDTPFSDELVIQQHIEAGISLADALNFIVEKYELVRTDRPGF
SIREQSPFITSIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR
MQTKSPPFMRAASSRPSPVGVWQTLLTCLLEHHYGLTLNDTPFSDELVIQQHIEAGISLADALNFIVEKYELVRTDRPGF
SIREQSPFITSIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR
Download Length: 390 bp
>T228059 NZ_CP123266:290452-290979 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13416.24 Da Isoelectric Point: 7.0268
>AT228059 WP_014837280.1 NZ_CP089315:c5393854-5393495 [Klebsiella michiganensis]
MSKKTTIATHDISESWWGLRRSVSACFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQSFPVLMKQLELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSHGYVYIAIYPTPVTTE
MSKKTTIATHDISESWWGLRRSVSACFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQSFPVLMKQLELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSHGYVYIAIYPTPVTTE
Download Length: 360 bp
>AT228059 NZ_CP123266:290179-290445 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A486SQP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7H4M120 |