Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4881818..4882637 Replicon chromosome
Accession NZ_CP089315
Organism Klebsiella michiganensis strain K92

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag LT984_RS23380 Protein ID WP_004110819.1
Coordinates 4882380..4882637 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag LT984_RS23375 Protein ID WP_014837489.1
Coordinates 4881818..4882369 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT984_RS23345 (LT984_23345) 4877742..4878515 + 774 WP_088168442.1 Zygote formation protein zyg1 -
LT984_RS23350 (LT984_23350) 4878826..4879299 + 474 WP_032693194.1 hypothetical protein -
LT984_RS23355 (LT984_23355) 4879568..4879917 - 350 Protein_4599 type II toxin-antitoxin system VapC family toxin -
LT984_RS23360 (LT984_23360) 4879980..4880138 - 159 Protein_4600 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LT984_RS23365 (LT984_23365) 4880172..4880918 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
LT984_RS23370 (LT984_23370) 4881342..4881704 - 363 Protein_4602 class I SAM-dependent methyltransferase -
LT984_RS23375 (LT984_23375) 4881818..4882369 - 552 WP_014837489.1 N-acetyltransferase Antitoxin
LT984_RS23380 (LT984_23380) 4882380..4882637 - 258 WP_004110819.1 YjhX family toxin Toxin
LT984_RS23385 (LT984_23385) 4883313..4884497 + 1185 WP_014228054.1 mannonate dehydratase -
LT984_RS23390 (LT984_23390) 4884571..4886046 + 1476 WP_014228053.1 fructuronate reductase -
LT984_RS23395 (LT984_23395) 4886185..4886961 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T228057 WP_004110819.1 NZ_CP089315:c4882637-4882380 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T228057 NZ_CP123266:194223-194330 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19902.64 Da        Isoelectric Point: 6.4913

>AT228057 WP_014837489.1 NZ_CP089315:c4882369-4881818 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT228057 NZ_CP123266:c194166-194111 [Escherichia coli]
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References