Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
| Location | 4547563..4548179 | Replicon | chromosome |
| Accession | NZ_CP089313 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q8Z2U3 |
| Locus tag | LT987_RS22000 | Protein ID | WP_000238494.1 |
| Coordinates | 4547563..4547937 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A8E9YHE9 |
| Locus tag | LT987_RS22005 | Protein ID | WP_001523745.1 |
| Coordinates | 4547937..4548179 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LT987_RS21985 (4545065) | 4545065..4545967 | + | 903 | WP_051129234.1 | formate dehydrogenase subunit beta | - |
| LT987_RS21990 (4545964) | 4545964..4546599 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LT987_RS21995 (4546596) | 4546596..4547525 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| LT987_RS22000 (4547563) | 4547563..4547937 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LT987_RS22005 (4547937) | 4547937..4548179 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | Antitoxin |
| LT987_RS22010 (4548384) | 4548384..4549313 | + | 930 | WP_001162861.1 | alpha/beta hydrolase | - |
| LT987_RS22015 (4549399) | 4549399..4549710 | + | 312 | WP_000558165.1 | type II toxin-antitoxin system HigB family toxin | - |
| LT987_RS22020 (4549707) | 4549707..4550153 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | - |
| LT987_RS22025 (4550168) | 4550168..4551109 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LT987_RS22030 (4551154) | 4551154..4551591 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| LT987_RS22035 (4551588) | 4551588..4552460 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LT987_RS22040 (4552454) | 4552454..4553053 | - | 600 | WP_023227076.1 | glucose-1-phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13908.18 Da Isoelectric Point: 7.3567
>T228043 WP_000238494.1 NZ_CP089313:c4547937-4547563 [Salmonella enterica subsp. enterica serovar Indiana]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL
Download Length: 375 bp
>T228043 NZ_CP123260:3648843-3649385 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9437.77 Da Isoelectric Point: 4.4463
>AT228043 WP_001523745.1 NZ_CP089313:c4548179-4547937 [Salmonella enterica subsp. enterica serovar Indiana]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW
Download Length: 243 bp
>AT228043 NZ_CP123260:3648548-3648859 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|