Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4127082..4127598 Replicon chromosome
Accession NZ_CP089313
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag LT987_RS20090 Protein ID WP_000220577.1
Coordinates 4127082..4127366 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LT987_RS20095 Protein ID WP_000212724.1
Coordinates 4127356..4127598 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT987_RS20075 (4122198) 4122198..4123850 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
LT987_RS20080 (4124259) 4124259..4126397 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
LT987_RS20085 (4126614) 4126614..4127078 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LT987_RS20090 (4127082) 4127082..4127366 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT987_RS20095 (4127356) 4127356..4127598 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LT987_RS20100 (4127676) 4127676..4129589 - 1914 WP_023226980.1 BglG family transcription antiterminator -
LT987_RS20105 (4129606) 4129606..4130346 - 741 WP_000779254.1 KDGP aldolase family protein -
LT987_RS20110 (4130343) 4130343..4131461 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LT987_RS20115 (4131445) 4131445..4132578 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T228042 WP_000220577.1 NZ_CP089313:c4127366-4127082 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T228042 NZ_CP123260:3614868-3615086 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT228042 WP_000212724.1 NZ_CP089313:c4127598-4127356 [Salmonella enterica subsp. enterica serovar Indiana]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT228042 NZ_CP123260:3614468-3614842 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References