Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3427335..3427955 Replicon chromosome
Accession NZ_CP089313
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LT987_RS16880 Protein ID WP_001280991.1
Coordinates 3427737..3427955 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LT987_RS16875 Protein ID WP_000344807.1
Coordinates 3427335..3427709 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT987_RS16865 (3422474) 3422474..3423667 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LT987_RS16870 (3423690) 3423690..3426839 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
LT987_RS16875 (3427335) 3427335..3427709 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LT987_RS16880 (3427737) 3427737..3427955 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LT987_RS16885 (3428134) 3428134..3428685 + 552 WP_001278793.1 maltose O-acetyltransferase -
LT987_RS16890 (3428803) 3428803..3429273 + 471 WP_000136181.1 YlaC family protein -
LT987_RS16895 (3429329) 3429329..3429469 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LT987_RS16900 (3429475) 3429475..3429735 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LT987_RS16905 (3429960) 3429960..3431510 + 1551 WP_023210786.1 EAL domain-containing protein -
LT987_RS16915 (3431741) 3431741..3432130 + 390 WP_000961285.1 MGMT family protein -
LT987_RS16920 (3432163) 3432163..3432732 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T228038 WP_001280991.1 NZ_CP089313:3427737-3427955 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T228038 NZ_CP123260:c2498678-2498502 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT228038 WP_000344807.1 NZ_CP089313:3427335-3427709 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT228038 NZ_CP123260:c2498456-2498040 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References