228037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2449761..2450283 Replicon chromosome
Accession NZ_CP089313
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LT987_RS12010 Protein ID WP_000221343.1
Coordinates 2449999..2450283 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LT987_RS12005 Protein ID WP_000885424.1
Coordinates 2449761..2450009 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT987_RS11985 (2445403) 2445403..2446869 + 1467 WP_023893409.1 hypothetical protein -
LT987_RS23010 (2446900) 2446900..2447022 - 123 WP_254891910.1 hypothetical protein -
LT987_RS11990 (2447486) 2447486..2447773 + 288 WP_071787797.1 helix-turn-helix domain-containing protein -
LT987_RS11995 (2447845) 2447845..2448753 - 909 WP_077910000.1 hypothetical protein -
LT987_RS12000 (2448904) 2448904..2449236 - 333 WP_023227504.1 DUF1493 family protein -
LT987_RS12005 (2449761) 2449761..2450009 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LT987_RS12010 (2449999) 2449999..2450283 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT987_RS12015 (2450331) 2450331..2450531 + 201 Protein_2356 Rid family hydrolase -
LT987_RS12020 (2450583) 2450583..2451662 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LT987_RS12025 (2451855) 2451855..2452343 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
LT987_RS12030 (2452388) 2452388..2453896 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
LT987_RS12035 (2453886) 2453886..2455127 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2446918..2456753 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T228037 WP_000221343.1 NZ_CP089313:2449999-2450283 [Salmonella enterica subsp. enterica serovar Indiana]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T228037 NZ_CP123260:2047627-2047730 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT228037 WP_000885424.1 NZ_CP089313:2449761-2450009 [Salmonella enterica subsp. enterica serovar Indiana]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT228037 NZ_CP123260:c2047768-2047497 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAAATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References