Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1230038..1231661 Replicon chromosome
Accession NZ_CP089313
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag LT987_RS06105 Protein ID WP_000088046.1
Coordinates 1230038..1231363 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag LT987_RS06110 Protein ID WP_024136327.1
Coordinates 1231368..1231661 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT987_RS06075 (1226704) 1226704..1227003 - 300 WP_001572440.1 hypothetical protein -
LT987_RS06080 (1227058) 1227058..1227294 - 237 Protein_1193 type I restriction-modification system subunit M N-terminal domain-containing protein -
LT987_RS06085 (1227752) 1227752..1228177 - 426 WP_001043843.1 hypothetical protein -
LT987_RS06090 (1228431) 1228431..1229246 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
LT987_RS06095 (1229259) 1229259..1229669 - 411 WP_000985911.1 hypothetical protein -
LT987_RS06100 (1229771) 1229771..1229977 - 207 WP_000134171.1 hypothetical protein -
LT987_RS06105 (1230038) 1230038..1231363 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
LT987_RS06110 (1231368) 1231368..1231661 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
LT987_RS06115 (1232265) 1232265..1232657 - 393 WP_000341066.1 hypothetical protein -
LT987_RS06120 (1233030) 1233030..1233374 + 345 WP_223572079.1 hypothetical protein -
LT987_RS06125 (1233421) 1233421..1234125 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
LT987_RS06130 (1234214) 1234214..1234786 - 573 WP_000190920.1 flagellar phase variation DNA invertase Hin -
LT987_RS06135 (1234878) 1234878..1236398 + 1521 WP_000079792.1 FliC/FljB family flagellin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / tet(A) - 1195834..1244078 48244
- flank IS/Tn - - 1233421..1234125 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T228028 WP_000088046.1 NZ_CP089313:c1231363-1230038 [Salmonella enterica subsp. enterica serovar Indiana]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T228028 NZ_CP123260:c49729-49352 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT228028 WP_024136327.1 NZ_CP089313:c1231661-1231368 [Salmonella enterica subsp. enterica serovar Indiana]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT228028 NZ_CP123260:c50150-49776 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References