228024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-ParD
Location 7435135..7435699 Replicon chromosome
Accession NZ_CP089312
Organism Streptomyces sp. GQFP

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LUX31_RS33700 Protein ID WP_235479092.1
Coordinates 7435352..7435699 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LUX31_RS33695 Protein ID WP_235479091.1
Coordinates 7435135..7435365 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX31_RS33675 (LUX31_33675) 7430181..7431119 + 939 WP_235479088.1 EamA family transporter -
LUX31_RS33680 (LUX31_33680) 7431565..7431792 + 228 Protein_6687 winged helix-turn-helix domain-containing protein -
LUX31_RS33685 (LUX31_33685) 7431861..7434452 - 2592 WP_235479089.1 aminopeptidase N -
LUX31_RS33690 (LUX31_33690) 7434564..7435064 + 501 WP_235479090.1 DUF1203 domain-containing protein -
LUX31_RS33695 (LUX31_33695) 7435135..7435365 + 231 WP_235479091.1 ribbon-helix-helix domain-containing protein Antitoxin
LUX31_RS33700 (LUX31_33700) 7435352..7435699 + 348 WP_235479092.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LUX31_RS33705 (LUX31_33705) 7435792..7436811 - 1020 WP_235479093.1 aspartate-semialdehyde dehydrogenase -
LUX31_RS33710 (LUX31_33710) 7437048..7437749 - 702 WP_235479094.1 TetR/AcrR family transcriptional regulator -
LUX31_RS33715 (LUX31_33715) 7437888..7439504 + 1617 WP_235479095.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12555.50 Da        Isoelectric Point: 10.1033

>T228024 WP_235479092.1 NZ_CP089312:7435352-7435699 [Streptomyces sp. GQFP]
MNRGEIYLVDLDPAVGSEANKTRPAILVTNNAANRMADRAGRGVLAVVPVTSNITHVRPFQVLLHAAECGLRVDSKAQCE
QIRALDFSRIGHRIGTVPPHALKEIDRALRQQLAL

Download         Length: 348 bp

>T228024 NZ_CP123255:c4196683-4196306 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGTCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8568.37 Da        Isoelectric Point: 3.9067

>AT228024 WP_235479091.1 NZ_CP089312:7435135-7435365 [Streptomyces sp. GQFP]
MKISVSLPEDDVTFVDEYAAKKAAESRSAVIHAAIQMLRESALEEEYLAAWDEWYASEDAELWDRTVGDGISDESR

Download         Length: 231 bp

>AT228024 NZ_CP123255:c4197104-4196730 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References