228023

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 5658368..5658984 Replicon chromosome
Accession NZ_CP089312
Organism Streptomyces sp. GQFP

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LUX31_RS25280 Protein ID WP_235477261.1
Coordinates 5658565..5658984 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LUX31_RS25275 Protein ID WP_235477259.1
Coordinates 5658368..5658574 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX31_RS25250 (LUX31_25250) 5654251..5654463 + 213 WP_235477255.1 hypothetical protein -
LUX31_RS25255 (LUX31_25255) 5654460..5654663 + 204 WP_235480206.1 hypothetical protein -
LUX31_RS25260 (LUX31_25260) 5654709..5654999 - 291 WP_235480043.1 DUF6355 family natural product biosynthesis protein -
LUX31_RS25265 (LUX31_25265) 5655121..5655879 - 759 WP_235477256.1 TetR/AcrR family transcriptional regulator -
LUX31_RS25270 (LUX31_25270) 5655993..5658260 + 2268 WP_235477257.1 MMPL family transporter -
LUX31_RS25275 (LUX31_25275) 5658368..5658574 + 207 WP_235477259.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUX31_RS25280 (LUX31_25280) 5658565..5658984 + 420 WP_235477261.1 PIN domain nuclease Toxin
LUX31_RS25285 (LUX31_25285) 5659055..5659408 + 354 Protein_5016 MMPL family transporter -
LUX31_RS25290 (LUX31_25290) 5659488..5660351 - 864 WP_235477263.1 aldo/keto reductase -
LUX31_RS25295 (LUX31_25295) 5660348..5660938 - 591 WP_235477264.1 hypothetical protein -
LUX31_RS25300 (LUX31_25300) 5661063..5661596 - 534 WP_235477266.1 GNAT family N-acetyltransferase -
LUX31_RS25305 (LUX31_25305) 5661657..5662604 - 948 WP_235477268.1 N-acetylmuramic acid 6-phosphate etherase -
LUX31_RS25310 (LUX31_25310) 5662697..5663665 - 969 WP_235477271.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15204.45 Da        Isoelectric Point: 5.2289

>T228023 WP_235477261.1 NZ_CP089312:5658565-5658984 [Streptomyces sp. GQFP]
VAVERFLVDKSVWVRAGNPSVRAALMPLVQRGLLATCAVVDLEILFSARNGEEHAAGRSVRKGFEWLPLTDEIGARVIEV
QGLLAEKGMHREASIPDLLMAATAERHGVTVLHYDGDFEHIAEITGQPVEWVVERGSVP

Download         Length: 420 bp

>T228023 NZ_CP123255:c4160660-4160373 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7375.49 Da        Isoelectric Point: 4.4472

>AT228023 WP_235477259.1 NZ_CP089312:5658368-5658574 [Streptomyces sp. GQFP]
MSRTMIDLDDALIAEAAEILGTTTKRATVNGALAEFVAAAKRQRFMDMLEGGVFSDLGDPEVMAKAWR

Download         Length: 207 bp

>AT228023 NZ_CP123255:c4160386-4160084 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References