Detailed information of TA system TA228022

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5425313..5425874
• Replicon: chromosome
• Accession: NZ_CP089312
• Organism: Streptomyces sp. GQFP

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LUX31_RS24115
• Protein ID: WP_235477037.1
• Coordinates: 5425611..5425874 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LUX31_RS24110
• Protein ID: WP_235477036.1
• Coordinates: 5425313..5425579 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUX31_RS24065 (LUX31_24065)	5420439..5420651	-	213	WP_235477028.1	hypothetical protein	-
LUX31_RS24070 (LUX31_24070)	5420648..5420896	-	249	WP_235477029.1	hypothetical protein	-
LUX31_RS24075 (LUX31_24075)	5421006..5421770	+	765	WP_235477030.1	GntR family transcriptional regulator	-
LUX31_RS24080 (LUX31_24080)	5421898..5422215	+	318	WP_235477031.1	hypothetical protein	-
LUX31_RS24085 (LUX31_24085)	5422276..5423031	-	756	WP_235477032.1	hypothetical protein	-
LUX31_RS24090 (LUX31_24090)	5423035..5423280	-	246	WP_235477033.1	hypothetical protein	-
LUX31_RS24095 (LUX31_24095)	5423528..5423665	+	138	WP_235477034.1	hypothetical protein	-
LUX31_RS24100 (LUX31_24100)	5424273..5424827	+	555	WP_235477035.1	hypothetical protein	-
LUX31_RS24105 (LUX31_24105)	5424847..5425020	+	174	Protein_4784	leucine-rich repeat domain-containing protein	-
LUX31_RS24110 (LUX31_24110)	5425313..5425579	+	267	WP_235477036.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LUX31_RS24115 (LUX31_24115)	5425611..5425874	+	264	WP_235477037.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LUX31_RS24120 (LUX31_24120)	5425922..5426416	-	495	WP_235477038.1	hypothetical protein	-
LUX31_RS24125 (LUX31_24125)	5426571..5427554	-	984	WP_235477039.1	YihY/virulence factor BrkB family protein	-
LUX31_RS24130 (LUX31_24130)	5427622..5428272	-	651	WP_235477040.1	GTP cyclohydrolase II	-
LUX31_RS24135 (LUX31_24135)	5428392..5428904	-	513	WP_235477041.1	MarR family transcriptional regulator	-
LUX31_RS24140 (LUX31_24140)	5429049..5430188	+	1140	WP_235477042.1	dihydrofolate reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9953.39 Da
• Isoelectric Point: 9.5565

>T228022 WP_235477037.1 NZ_CP089312:5425611-5425874 [Streptomyces sp. GQFP]
VSEYRTVFRPEAQAELRKIPRDAALRILAKLTELETDPLGFSTTALVSQPERRRLRVGDYRVIYTIDNGELVVWVVHVGH
RSTVYGT

Nucleotide

• Length: 264 bp

>T228022 NZ_CP123255:3826273-3826551 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10229.72 Da
• Isoelectric Point: 4.9572

>AT228022 WP_235477036.1 NZ_CP089312:5425313-5425579 [Streptomyces sp. GQFP]
MTQMPIESIRAVRAHLAEVVERADRDDMPTVITRRGKEVAAVVSIEVLRRYQEWEEREINRIIDERMANRVAGVPIEDVM
RETLARGE

Nucleotide

• Length: 267 bp

>AT228022 NZ_CP123255:3826010-3826270 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA