228019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4698260..4698888 Replicon chromosome
Accession NZ_CP089312
Organism Streptomyces sp. GQFP

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LUX31_RS20715 Protein ID WP_235476284.1
Coordinates 4698260..4698670 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LUX31_RS20720 Protein ID WP_235476288.1
Coordinates 4698667..4698888 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX31_RS20690 (LUX31_20690) 4693647..4693871 + 225 WP_235476279.1 hypothetical protein -
LUX31_RS20695 (LUX31_20695) 4694321..4694557 - 237 WP_235476280.1 hypothetical protein -
LUX31_RS20700 (LUX31_20700) 4694811..4695602 + 792 WP_235476281.1 helix-turn-helix transcriptional regulator -
LUX31_RS20705 (LUX31_20705) 4696137..4697837 + 1701 WP_235476282.1 hypothetical protein -
LUX31_RS20710 (LUX31_20710) 4697834..4698217 + 384 WP_235476283.1 hypothetical protein -
LUX31_RS20715 (LUX31_20715) 4698260..4698670 - 411 WP_235476284.1 PIN domain-containing protein Toxin
LUX31_RS20720 (LUX31_20720) 4698667..4698888 - 222 WP_235476288.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUX31_RS20725 (LUX31_20725) 4699616..4700074 + 459 WP_235476289.1 helix-turn-helix domain-containing protein -
LUX31_RS20730 (LUX31_20730) 4700157..4700645 + 489 WP_235476296.1 PIN domain-containing protein -
LUX31_RS20735 (LUX31_20735) 4700743..4701069 - 327 WP_235476297.1 hypothetical protein -
LUX31_RS20740 (LUX31_20740) 4701147..4702523 - 1377 WP_235476299.1 FtsK/SpoIIIE domain-containing protein -
LUX31_RS20745 (LUX31_20745) 4702523..4702879 - 357 WP_235476301.1 hypothetical protein -
LUX31_RS20750 (LUX31_20750) 4703049..4703837 - 789 WP_235476305.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14878.60 Da        Isoelectric Point: 6.1486

>T228019 WP_235476284.1 NZ_CP089312:c4698670-4698260 [Streptomyces sp. GQFP]
VIYLLDTSGLVRLLRDPKLQSAWHDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDAAVPKNAGRWIGGVQ
HRMARAGEHRSASAVDLVIAATAAHHGLAVLHDDADYGTVARHASDLTEHNVHDIV

Download         Length: 411 bp

>T228019 NZ_CP123255:2715042-2715149 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8492.48 Da        Isoelectric Point: 6.7275

>AT228019 WP_235476288.1 NZ_CP089312:c4698888-4698667 [Streptomyces sp. GQFP]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKNSR

Download         Length: 222 bp

>AT228019 NZ_CP123255:c2714995-2714929 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References