228018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 4522716..4523243 Replicon chromosome
Accession NZ_CP089312
Organism Streptomyces sp. GQFP

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LUX31_RS19910 Protein ID WP_235476134.1
Coordinates 4522716..4522976 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LUX31_RS19915 Protein ID WP_235476135.1
Coordinates 4522989..4523243 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX31_RS19885 (LUX31_19885) 4519914..4520378 - 465 WP_235476131.1 GatB/YqeY domain-containing protein -
LUX31_RS19890 (LUX31_19890) 4520457..4521380 + 924 WP_235476132.1 metallophosphoesterase -
LUX31_RS19895 (LUX31_19895) 4521435..4522214 + 780 WP_235476133.1 Pr6Pr family membrane protein -
LUX31_RS19905 (LUX31_19905) 4522408..4522626 - 219 Protein_3959 site-specific integrase -
LUX31_RS19910 (LUX31_19910) 4522716..4522976 - 261 WP_235476134.1 Txe/YoeB family addiction module toxin Toxin
LUX31_RS19915 (LUX31_19915) 4522989..4523243 - 255 WP_235476135.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LUX31_RS19920 (LUX31_19920) 4523512..4526190 + 2679 WP_235476136.1 ATP/GTP-binding protein -
LUX31_RS19925 (LUX31_19925) 4526247..4527140 + 894 WP_235479985.1 HNH endonuclease -
LUX31_RS19930 (LUX31_19930) 4527203..4527481 + 279 WP_235476137.1 ribbon-helix-helix domain-containing protein -
LUX31_RS19935 (LUX31_19935) 4527478..4527903 + 426 WP_235476138.1 PIN domain-containing protein -
LUX31_RS19940 (LUX31_19940) 4527947..4528171 - 225 Protein_3966 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10336.75 Da        Isoelectric Point: 9.4248

>T228018 WP_235476134.1 NZ_CP089312:c4522976-4522716 [Streptomyces sp. GQFP]
MKITFSSRAWEDYLWWQLQDRKILKRINTLIADIARNGNEGIGKPEPLKHGFQGYWSRRINDEHRLIYKATEDGVLIAQC
RYHYEN

Download         Length: 261 bp

>T228018 NZ_CP123255:2714507-2714614 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9371.41 Da        Isoelectric Point: 4.4002

>AT228018 WP_235476135.1 NZ_CP089312:c4523243-4522989 [Streptomyces sp. GQFP]
VKTMTYSESRARYAEVLNAVTDDREEVVITRAGHEPVVIVSLEDYESLKETAYLLRSPSNARRLLASIDELENGGGTVRE
LTTD

Download         Length: 255 bp

>AT228018 NZ_CP123255:c2714460-2714394 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References