Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4947583..4948238 Replicon chromosome
Accession NZ_CP089309
Organism Thiocapsa bogorovii strain BBS

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LT988_RS22035 Protein ID WP_232407645.1
Coordinates 4947583..4948005 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LT988_RS22040 Protein ID WP_232407647.1
Coordinates 4948002..4948238 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT988_RS22005 (LT988_22005) 4943392..4944036 + 645 WP_232407637.1 protein-methionine-sulfoxide reductase heme-binding subunit MsrQ -
LT988_RS22010 (LT988_22010) 4944284..4945018 - 735 WP_232407638.1 class I SAM-dependent methyltransferase -
LT988_RS22015 (LT988_22015) 4945764..4945925 - 162 WP_232407640.1 hypothetical protein -
LT988_RS22020 (LT988_22020) 4945939..4946907 - 969 WP_232407642.1 N-6 DNA methylase -
LT988_RS22025 (LT988_22025) 4946904..4947092 - 189 WP_232407643.1 hypothetical protein -
LT988_RS22030 (LT988_22030) 4947235..4947516 - 282 WP_232407644.1 type I restriction-modification system subunit M N-terminal domain-containing protein -
LT988_RS22035 (LT988_22035) 4947583..4948005 - 423 WP_232407645.1 PIN domain-containing protein Toxin
LT988_RS22040 (LT988_22040) 4948002..4948238 - 237 WP_232407647.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LT988_RS22045 (LT988_22045) 4948377..4948709 - 333 WP_232407649.1 helix-turn-helix domain-containing protein -
LT988_RS22050 (LT988_22050) 4948857..4949159 - 303 WP_232407651.1 hypothetical protein -
LT988_RS22055 (LT988_22055) 4949156..4949920 - 765 WP_232407652.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
LT988_RS22060 (LT988_22060) 4949845..4950351 - 507 WP_232407654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15430.59 Da        Isoelectric Point: 4.3147

>T228013 WP_232407645.1 NZ_CP089309:c4948005-4947583 [Thiocapsa bogorovii]
VTTETDFFDTNVVLYLLSEDEIKANRAEALLAAGGTISVQVLNEFVSVARRKLGCDWAEVRDILETIRALCPVQPLTIEV
HDLGLRLAERYGLAIYDAMIAASALDCGCTTLWSEDFQDGQILDGRLRVRNPFVTSPGRA

Download         Length: 423 bp

>T228013 NZ_CP123255:1852313-1852564 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9105.40 Da        Isoelectric Point: 8.7067

>AT228013 WP_232407647.1 NZ_CP089309:c4948238-4948002 [Thiocapsa bogorovii]
MQISKWGNSLAVRLPAAVIEALALKEGDDIEIVVADERRFEVRRKPTRTELIERLRAYRGRLPADFRFDRLESHEDRG

Download         Length: 237 bp

>AT228013 NZ_CP123255:1852561-1852815 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATTATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References