Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1229023..1229570 Replicon chromosome
Accession NZ_CP089309
Organism Thiocapsa bogorovii strain BBS

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LT988_RS05535 Protein ID WP_232409229.1
Coordinates 1229023..1229349 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LT988_RS05540 Protein ID WP_232409230.1
Coordinates 1229346..1229570 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT988_RS05510 (LT988_05510) 1224459..1225514 - 1056 WP_232409224.1 AAA family ATPase -
LT988_RS05515 (LT988_05515) 1225550..1228060 - 2511 WP_232409225.1 transposase -
LT988_RS05520 (LT988_05520) 1228111..1228485 - 375 WP_232409226.1 type II toxin-antitoxin system VapC family toxin -
LT988_RS05525 (LT988_05525) 1228482..1228682 - 201 WP_232409227.1 type II toxin-antitoxin system VapB family antitoxin -
LT988_RS05530 (LT988_05530) 1228847..1229026 - 180 WP_232409228.1 hypothetical protein -
LT988_RS05535 (LT988_05535) 1229023..1229349 - 327 WP_232409229.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LT988_RS05540 (LT988_05540) 1229346..1229570 - 225 WP_232409230.1 antitoxin MazE family protein Antitoxin
LT988_RS05545 (LT988_05545) 1229820..1232549 - 2730 WP_232409231.1 BREX system P-loop protein BrxC -
LT988_RS05550 (LT988_05550) 1232659..1234053 + 1395 WP_232406659.1 IS1380-like element ISTro1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1232659..1234053 1394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(8-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11731.81 Da        Isoelectric Point: 10.0121

>T228008 WP_232409229.1 NZ_CP089309:c1229349-1229023 [Thiocapsa bogorovii]
MTRGDLVTIVIPGDFGKPRPALVIQADQFHEHATRTVLPVTSTLVAAPLFRITLEPSGENGLTKPSQVMVDKAMTVKRDK
VGPVFGRIDLDKLVEIERALAVFLGIAK

Download         Length: 327 bp

>T228008 NZ_CP123255:710256-710552 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8378.37 Da        Isoelectric Point: 8.0619

>AT228008 WP_232409230.1 NZ_CP089309:c1229570-1229346 [Thiocapsa bogorovii]
MASTHVNTRVQKHRAALRRAGLRPVQIWVPDTRRAGFAEECRRQSRLAAQADAADSDMQQWMDEALTDLDGWSA

Download         Length: 225 bp

>AT228008 NZ_CP123255:710554-710949 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References